Palladium-catalyzed three-component cyclization: Synthesis of hydroisoindol-1-ones from 2-bromocyclohex-1-enecarbaldehydes, anilines and carbon monoxide

被引：28
作者：
Cho, Chan Sik [1 ]
Kim, Hyo Bo [1 ]
Lee, Sang Yeon [1 ]
机构：
[1] Kyungpook Natl Univ, Dept Appl Chem, Taegu 702701, South Korea
来源：
JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2010年 / 695卷 / 12-13期
关键词：
Anilines; 2-Bromocyclohex-1-enecarbaldehydes; Carbonylation; Cyclization; Hydroisoindol-1-ones; Palladium catalyst; BETA-BROMOVINYL ALDEHYDES; SUBSTITUTED BENZENE-DERIVATIVES; CARBONYLATIVE CYCLIZATION; OXIDATIVE CYCLIZATION; 2-BROMOBENZALDEHYDE; ISOINDOLINONES; AROMATIZATION; LACTONES; ACCESS;
D O I：
10.1016/j.jorganchem.2010.03.025
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
2-Bromocyclohex-1-enecarbaldehydes react with anilines under carbon monoxide pressure in DMF at 60 degrees C in the presence of acatalytic amount of PdCl(2)(PhCN)(2) to afford the corresponding hydroisoindol-1-ones in good yields. (C) 2010 Elsevier B.V. All rights reserved.
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页码：1744 / 1748
页数：5
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