Antifungal Agents in Agriculture: Friends and Foes of Public Health

被引：189
作者：
Brauer, Veronica Soares [1 ]
Rezende, Caroline Patini [1 ]
Pessoni, Andre Moreira [1 ]
De Paula, Renato Graciano [2 ]
Rangappa, Kanchugarakoppal S. [3 ]
Nayaka, Siddaiah Chandra [4 ]
Gupta, Vijai Kumar [5 ]
Almeida, Fausto [1 ]
机构：
[1] Univ Sao Paulo, Dept Biochem & Immunol, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP, Brazil
[2] Univ Fed Espirito Santo, Dept Physiol Sci, Hlth Sci Ctr, BR-29047105 Vitoria, ES, Brazil
[3] Univ Mysore, Dept Studies Chem, Mysore 570006, Karnataka, India
[4] Univ Mysore, Dept Studies Biotechnol, Mysore 570006, Karnataka, India
[5] Tallinn Univ Technol, Dept Chem & Biotechnol, ERA Chair Green Chem, EE-12618 Tallinn, Estonia
来源：
BIOMOLECULES | 2019年 / 9卷 / 10期
关键词：
Antifungal agents; fungicides; agriculture; chemoinformatics; UNDERSTANDING MOLECULAR-MECHANISMS; BOTRYTIS-CINEREA; ASPERGILLUS-FUMIGATUS; FUNGICIDE RESISTANCE; AZOLE RESISTANCE; ENDOPHYTIC FUNGUS; ANILINOPYRIMIDINE FUNGICIDES; COPPER NANOPARTICLES; DRUG-RESISTANCE; FIELD STRAINS;
D O I：
10.3390/biom9100521
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Fungal diseases have been underestimated worldwide but constitute a substantial threat to several plant and animal species as well as to public health. The increase in the global population has entailed an increase in the demand for agriculture in recent decades. Accordingly, there has been worldwide pressure to find means to improve the quality and productivity of agricultural crops. Antifungal agents have been widely used as an alternative for managing fungal diseases affecting several crops. However, the unregulated use of antifungals can jeopardize public health. Application of fungicides in agriculture should be under strict regulation to ensure the toxicological safety of commercialized foods. This review discusses the use of antifungals in agriculture worldwide, the need to develop new antifungals, and improvement of regulations regarding antifungal use.
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页数：21
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