Interactions between cellular actin and human respiratory syncytial virus (HRSV)

被引：65

作者：

Ulloa, L

Serra, R

Asenjo, A

Villanueva, N

机构：

[1] Inst Salud Carlos 3, CNM, Serv Virol, E-28220 Madrid, Spain

[2] Univ Autonoma Madrid, CSIC, Ctr Biol Mol Severo Ochoa, E-28049 Madrid, Spain

来源：

VIRUS RESEARCH | 1998年 / 53卷 / 01期

关键词：

HRSV; actin; interactions; polymerization; motility;

D O I：

10.1016/S0168-1702(97)00121-4

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Actin the main component of the cellular microfilament network, is present in human respiratory syncytial virus (HRSV) purified virions, as an internal component. This fact and the results of immunoprecipitation studies indicate that during HRSV infection in HEp-2 cells there are interactions between cellular actin and viral components, that can promote a transitory increase in the polymerization of synthetized actin, mainly of the beta isotype. This increased actin polymerization can be related with the formation of cytoplasmic extensions, that contain beta actin and viral particles observed in the HRSV infected HEp-2 cells. The formation of these structures may indicate that HRSV has developed an actin-based motility system similar to that described for other viral and bacterial systems. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：13 / 25

页数：13

共 35 条

[1] DIRECT OBSERVATION OF THE BUDDING AND FUSION OF AN ENVELOPED VIRUS BY VIDEO MICROSCOPY OF VIABLE CELLS [J].