Synthesis and antitumor activity of bis(arylsulfonyl)dihydroimidazolinone derivatives

被引：5

作者：

Sittihan, Satapanawat ^{[1
]}

Jumpathong, Watthanachai ^{[1
]}

Sopha, Pattarawut ^{[2
]}

Ruchirawat, Somsak ^{[1
,3
]}

机构：

[1] Minist Educ, Chulabhorn Grad Inst, Ctr Excellence Environm Hlth & Toxicol EHT, Program Chem Biol, 906 Kamphaeng Phet 6, Bangkok 10210, Thailand

[2] Minist Educ, Chulabhorn Grad Inst, Program Appl Biol Sci, Ctr Excellence Environm Hlth & Toxicol EHT, 906 Kamphaeng Phet 6, Bangkok 10210, Thailand

[3] Chulabhorn Res Inst, Lab Med Chem, 54 Kamphaeng Phet 6, Bangkok 10210, Thailand

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2020年 / 30卷 / 01期

关键词：

Bis(arylsulfonyl)dihydroimidazolinones; Cytotoxicity; Antitumor; IN-VIVO; IMIDAZOLIDINONE MOTIF; ARYLSULFONYLIMIDAZOLIDINONES; DIARYLSULFONYLUREAS; EFFICACY; AGENTS; 4-PHENYL-1-ARYLSULFONYLIMIDAZOLIDINONES; CHEMOTHERAPY; CYTOTOXICITY; SULFONYLUREA;

D O I：

10.1016/j.bmcl.2019.126776

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel bis(arylsulfonyl)dihydroimidazolinones with different aryl substitution patterns were readily synthesized and evaluated for their antitumor activities. Some of the newly synthesized compounds exhibited cytotoxicity at micromolar range against multiple cancer cell lines, including A549, HepG2, HuCCA-1, and MOLT-3. The most potent analogue contained pentafluorobenzenesulfonyl groups, which could be chemically elaborated to serve as a potential pharmacophore.

引用

页数：5

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