An introduction to electrochemical DNA biosensors

被引:208
作者
Odenthal, Katherine J. [1 ]
Gooding, J. Justin [1 ]
机构
[1] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia
关键词
D O I
10.1039/b701816a
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
Electrochemical DNA biosensors exploit the affinity of single-stranded DNA for complementary strands of DNA and are used in the detection of specific sequences of DNA with a view towards developing portable analytical devices. Great progress has been made in this field but there are still numerous challenges to overcome. This review for researchers new to the field describes the components of electrochemical DNA biosensors and the important issues in their design. Methods of transducing DNA binding events are discussed along with future directions for DNA biosensors.
引用
收藏
页码:603 / 610
页数:8
相关论文
共 98 条
[21]  
Erdem A, 2002, ELECTROANAL, V14, P965, DOI 10.1002/1521-4109(200208)14:14<965::AID-ELAN965>3.0.CO
[22]  
2-U
[23]  
Erdem A, 1999, ELECTROANAL, V11, P1372, DOI 10.1002/(SICI)1521-4109(199912)11:18<1372::AID-ELAN1372>3.0.CO
[24]  
2-4
[25]   Electrochemical interrogation of conformational changes as a reagentless method for the sequence-specific detection of DNA [J].
Fan, CH ;
Plaxco, KW ;
Heeger, AJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (16) :9134-9137
[26]   Coupling of a reagentless electrochemical DNA biosensor with conducting polymer film and nanocomposite as matrices for the detection of the HIV DNA sequences [J].
Fu, YZ ;
Yuan, R ;
Chai, YQ ;
Zhou, L ;
Zhang, Y .
ANALYTICAL LETTERS, 2006, 39 (03) :467-482
[27]   Indicator free DNA hybridization detection via EIS based on self-assembled gold nanoparticles and bilayer two-dimensional 3-mercaptopropyltrimethoxysilane onto a gold substrate [J].
Fu, YZ ;
Yuan, R ;
Xu, L ;
Chai, YQ ;
Zhong, X ;
Tang, DP .
BIOCHEMICAL ENGINEERING JOURNAL, 2005, 23 (01) :37-44
[28]  
Gooding JJ, 2002, ELECTROANAL, V14, P1149, DOI 10.1002/1521-4109(200209)14:17<1149::AID-ELAN1149>3.0.CO
[29]  
2-8
[30]   Nucleic acid biosensors based upon surface-assembled monolayers: exploiting and enhancing materials properties [J].
Gooding, JJ ;
King, GC .
JOURNAL OF MATERIALS CHEMISTRY, 2005, 15 (46) :4876-4880