Infliximab and insulin resistance

被引：27

作者：

Ursini, Francesco ^{[1
]}

Naty, Saverio ^{[1
]}

Grembiale, Rosa Daniela ^{[1
]}

机构：

[1] Univ Catanzaro UMG, Dept Expt & Clin Med, Rheumatol Res Unit, Catanzaro, Italy

来源：

AUTOIMMUNITY REVIEWS | 2010年 / 9卷 / 08期

关键词：

Infliximab; TNF-alpha; Insulin resistance; Inflammation; TUMOR-NECROSIS-FACTOR; TYROSINE KINASE-ACTIVITY; FACTOR-ALPHA BLOCKADE; ANTI-TNF TREATMENT; RHEUMATOID-ARTHRITIS; PSORIATIC-ARTHRITIS; ADIPOSE-TISSUE; WEIGHT-LOSS; OBESITY; SENSITIVITY;

D O I：

10.1016/j.autrev.2009.12.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Insulin resistance is the most important pathophysiologic feature of obesity, type 2 diabetes mellitus and prediabetic states. TNF-alpha, a proinflammatory cytokine, plays a pivotal role in the pathogenesis of inflammation-associated insulin resistance during the course of rheumatic diseases. Therapies aimed at neutralizing TNF-alpha, such as the monoclonal antibody infliximab, represent a novel approach for the treatment of rheumatic diseases and allow to obtain significant results in terms of control of the inflammatory process. In this article we reviewed the scientific evidence published in the literature about a potential role of TNF-alpha blockade in improving insulin resistance in non-diabetic rheumatic patients. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：536 / 539

页数：4

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