Afferent Nerves Regulating the Cough Reflex: Mechanisms and Mediators of Cough in Disease

被引：56

作者：

Canning, Brendan J. ^{[1
]}

机构：

[1] Johns Hopkins Asthma & Allergy Ctr, Dept Med, Div Clin Immunol & Allergy, Baltimore, MD 21224 USA

来源：

OTOLARYNGOLOGIC CLINICS OF NORTH AMERICA | 2010年 / 43卷 / 01期

基金：

美国国家卫生研究院;

关键词：

Capsaicin; Vagal; Bradykinin; N-Methyl-D-Aspartate; ANESTHETIZED GUINEA-PIGS; ACID-INDUCED COUGH; GASTROESOPHAGEAL-REFLUX; CITRIC-ACID; C-FIBERS; ANTITUSSIVE ACTIVITY; PROSTAGLANDIN E-2; SENSORY NEURONS; SUBSTANCE-P; CAPSAICIN;

D O I：

10.1016/j.otc.2009.11.012

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Bronchopulmonary C fibers and acid-sensitive, capsaicin-insensitive mechanoreceptors innervating the larynx, trachea, and large bronchi regulate the cough reflex. These vagal afferent nerves may interact centrally with sensory input arising from afferent nerves innervating the intrapulmonary airways or even extrapulmonary afferents such as those innervating the nasal mucosa and esophagus to produce chronic cough or enhanced cough responsiveness. The mechanisms of cough initiation in health and in disease are briefly described.

引用

页码：15 / +

页数：12

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