Association between acute hypobaric hypoxia and activation of coagulation in human beings

被引：192

作者：

Bendz, B ^{[1
]}

Rostrup, M

Sevre, K

Andersen, TO

Sandset, PM

机构：

[1] Ulleval Univ Hosp, Haematol Res Lab, N-0407 Oslo, Norway

[2] Ulleval Univ Hosp, Div Med, N-0407 Oslo, Norway

来源：

LANCET | 2000年 / 356卷 / 9242期

关键词：

D O I：

10.1016/S0140-6736(00)03165-2

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The risk of venous thrombosis is thought to be increased by flying. In a study of 20 healthy male volunteers who were suddenly exposed to a hypobaric environment similar to that encountered within aeroplane cabins, markers of activated coagulation transiently increased by two-fold to eight-fold. We suggest that hypobaric hypoxia, with sedentariness and dehydration, may cause this Increased risk of venous thrombosis.

引用

页码：1657 / 1658

页数：2

共 5 条

[1] A new sensitive chromogenic substrate assay of tissue factor pathway inhibitor type 1 [J].

Bendz, B ;

Andersen, TO ;

Sandset, PM .

THROMBOSIS RESEARCH, 2000, 97 (06) :463-472

[2] ALTITUDE EXPOSURES DURING AIRCRAFT FLIGHT - FLYING HIGHER [J].

COTTRELL, JJ .

CHEST, 1988, 93 (01) :81-84

[3] Venous thromboembolism in association with prolonged air travel [J].

Eklof, B ;

Kistner, RL ;

Masuda, EM ;

Sonntag, BV ;

Wong, HP .

DERMATOLOGIC SURGERY, 1996, 22 (07) :637-641

[4]

Ostergaard PB, 1997, THROMB RES, V87, P447

[5] ENDOTOXIN-INDUCED COAGULANT ACTIVITY OF HUMAN MONOCYTES [J].

RIVERS, RPA ;

HATHAWAY, WE ;

WESTON, WL .

BRITISH JOURNAL OF HAEMATOLOGY, 1975, 30 (03) :311-316

← 1 →