Antioxidative characteristics and inhibition of α-melanocyte-stimulating hormone-stimulated melanogenesis of vanillin and vanillic acid from Origanum vulgare

被引：127
作者：
Chou, Tzung-Han [2 ]
Ding, Hsiou-Yu [1 ]
Hung, Wei Jing [2 ]
Liang, Chia-Hua [1 ,2 ]
机构：
[1] Chia Nan Univ Pharm & Sci, Inst Cosmet Sci, Tainan 717, Taiwan
[2] Chia Nan Univ Pharm & Sci, Dept Cosmet Sci, Tainan 717, Taiwan
来源：
EXPERIMENTAL DERMATOLOGY | 2010年 / 19卷 / 08期
关键词：
antioxidant; antimelanogenic; Origanum vulgare; vanillin; vanillic acid; IN-VITRO; TYROSINASE ACTIVITY; SKIN PIGMENTATION; OXIDATIVE STRESS; GENE-EXPRESSION; CANCER-CELLS; V79; CELLS; EXTRACT; REPAIR; CINNAMALDEHYDE;
D O I：
10.1111/j.1600-0625.2010.01091.x
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The antioxidant activities of vanillin and vanillic acid isolated from Origanum vulgare are investigated. These compounds may serve as agents for antimelanogenesis. Vanillic acid is a stronger antioxidant than vanillin, in terms of free radical scavenging activity, reducing power and inhibition of lipid peroxidation. The inhibition of cellular reactive oxygen species (ROS) in H2O2-treated BNLCL2 cells by vanillic acid exceeds that of ascorbic acid (AA) or trolox. In B16F0 cells stimulated with alpha-melanocyte-stimulating hormone (alpha-MSH), vanillic acid reduced cellular tyrosinase activity, DOPA oxidase and melanin contents, as well as down-regulated expressions of melanocortin-1 receptor (MC1R), microphthalmia-associated transcription factor (MITF), tyrosinase, tyrosinase-related proteins 2 (TRP-2) and TRP-1. Vanillin did not express inhibition of tyrosinase activity. These results supported that vanillic acid is a significantly stronger antioxidant than vanillin and exhibited stronger antimelanogenesis performance because of the structural presence of the carboxyl group.
引用
收藏
页码：742 / 750
页数：9
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