Neuroimmune metabolism: Uncovering the role of metabolic reprogramming in central nervous system disease

被引：5

作者：

Korshoj, Lee E. ^{[1
]}

Kielian, Tammy ^{[1
]}

机构：

[1] Univ Nebraska Med Ctr, Dept Pathol & Microbiol, 985900 Nebraska Med Ctr, Omaha, NE 68198 USA

来源：

JOURNAL OF NEUROCHEMISTRY | 2021年 / 158卷 / 01期

关键词：

MESENCHYMAL STEM-CELLS; BRAIN; MICROGLIA; GANGLIOSIDES; ITACONATE;

D O I：

10.1111/jnc.15376

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The rapidly expanding field of immunometabolism has highlighted an intricate association between the metabolic pathways that program cellular pro-inflammatory versus anti-inflammatory activity. This Special Issue on Neuroimmune Metabolism showcases a growing body of work characterizing the metabolic profiles of the major CNS-resident and peripheral immune cell players in neuroinflammation, neurodegeneration, and brain injury. The review articles address the roles of glycolytic, oxidative, and lipid metabolism that are associated with beneficial or detrimental properties in various neurological conditions, address unanswered questions in the field, and discuss promising avenues for future therapeutics.

引用

页码：8 / 13

页数：6

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