LncRNA HAND2-AS1 sponging miR-1275 suppresses colorectal cancer progression by upregulating KLF14

被引：89

作者：

Zhou, Jianwei ^{[1
]}

Lin, Jiejun ^{[1
]}

Zhang, Hui ^{[1
]}

Zhu, Fangchao ^{[1
]}

Xie, Raoying ^{[2
]}

机构：

[1] Wenzhou Med Univ, Wenzhou Ctr Hosp, Dingli Clin Inst, Dept Gastroenterol, Wenzhou 325000, Peoples R China

[2] Wenzhou Med Univ, Affiliated Hosp 1, Dept Radiat & Med Oncol, 32 Dajian Lane, Wenzhou 325000, Zhejiang, Peoples R China

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2018年 / 503卷 / 03期

关键词：

HAND2-AS1; Colorectal cancer; Proliferation; Invasion; miR-1275; KLF14; CELL PROGRESSION; PROLIFERATION; METASTASIS; CARCINOMA; INVASION; TRANSITION; EXPRESSION; MIGRATION; GROWTH;

D O I：

10.1016/j.bbrc.2018.07.125

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Long noncoding RNAs (IncRNAs) represent a novel type of noncoding RNAs of over 200 nucleotides, characterized by no or limited protein-coding potential. Although the function of IncRNAs attracts increasing attention recently, the relationship between IncRNA and colorectal cancer (CRC) remains further investigation. In our study, we found that IncRNA HAND2-AS1 was markedly downregulated in CRC tissues. And its expression level was negatively correlated with metastasis and advanced stage in CRC patients. Furthermore, we showed that HAND2-AS1 low expression predicted poor prognosis. Functionally, we found that overexpression of HAND2-AS1 obviously attenuated the proliferation and invasion of CRC cells. Ectopic expression of HAND2-AS1 also inhibited tumor propagation in vivo. In mechanism, HAND2-AS1 served as a sponge of miR-1275 which targeted KLF14. Through facilitating KLF14 expression, HAND2-AS1 suppressed CRC progression. In conclusion, our study demonstrated that HAND2-AS1 exerts a suppressive role in CRC by sponging miR-1275 and modulating KLF14 expression. (C) 2018 Elsevier Inc. All rights reserved.

引用

页码：1848 / 1853

页数：6

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