Straightforward synthetic route to gold(i)-thiolato glycoconjugate complexes bearing NHC ligands (NHC = N-heterocyclic carbene) and their promising anticancer activity

被引：25
|
作者：
Safir Filho, Mauro [1 ]
Scattolin, Thomas [2 ,3 ]
Dao, Pascal [1 ]
Tzouras, Nikolaos, V [2 ,3 ]
Benhida, Rachid [1 ,4 ]
Saab, Marina [2 ,3 ]
Van Hecke, Kristof [2 ,3 ]
Lippmann, Petra [5 ]
Martin, Anthony R. [1 ,6 ]
Ott, Ingo [5 ]
Nolan, Steven P. [2 ,3 ]
机构：
[1] Univ Cote dAzur, Inst Chim Nice, UMR7272, CNRS, Nice, France
[2] Univ Ghent, Dept Chem, Krygslaan 281,S-3, B-9000 Ghent, Belgium
[3] Univ Ghent, Ctr Sustainable Chem, Krygslaan 281,S-3, B-9000 Ghent, Belgium
[4] Mohammed VI Polytech Univ, Chem & Biochem Sci Green Proc Engn CBS GPE, Lot 660, Hay Moulay Rachid, Benguerir, Morocco
[5] Tech Univ Carolo Wilhelmina Braunschweig, Inst Med & Pharmaceut Chem, Beethovenstr 55, D-38106 Braunschweig, Germany
[6] Univ Montpellier, Inst Biomol Max Mousseron, CNRS, ENSCM,UMR5247, Montpellier, France
来源：
NEW JOURNAL OF CHEMISTRY | 2021年 / 45卷 / 22期
关键词：
AURANOFIN; CYTOTOXICITY; INHIBITION; AU(I);
D O I：
10.1039/d1nj02117f
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A simple and eco-friendly route to gold-NHC complexes bearing different thiosugars is reported. The reaction between [Au(NHC)Cl] precursors, the thiosugars and a weak base proceeds under air using technical grade acetone under mild conditions (60 degrees C, 1 h). The one-pot synthesis of the same complexes starting from the corresponding imidazolium salts was also investigated. The obtained complexes showed strong cytotoxic activities against selected cancer cell lines with IC50 values in the submicromolar to low micromolar concentration range.
引用
收藏
页码：9995 / 10001
页数：7
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