The Relationship of Redox With Hallmarks of Cancer: The Importance of Homeostasis and Context

被引：71

作者：

Xing, Faliang

Hu, Qiangsheng

Qin, Yi

Xu, Jin

Zhang, Bo

Yu, Xianjun

Wang, Wei

机构：

[1] Department of Pancreatic Surgery, Fudan University Shanghai Cancer Center, Shanghai

[2] Department of Oncology, Shanghai Medical College, Fudan University, Shanghai

[3] Shanghai Pancreatic Cancer Institute, Shanghai

[4] Pancreatic Cancer Institute, Fudan University, Shanghai

[5] Department of Thoracic Surgery, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai

来源：

FRONTIERS IN ONCOLOGY | 2022年 / 12卷

基金：

中国国家自然科学基金;

关键词：

redox homeostasis; antioxidant response; hallmarks of cancer; ROS; Nrf2; METABOLIC OXIDATIVE STRESS; FOXO TRANSCRIPTION FACTORS; ACTIVATED PROTEIN-KINASE; TUMOR-CELL SURVIVAL; SUPEROXIDE-DISMUTASE; GLUCOSE DEPRIVATION; BREAST-CANCER; SIGNALING PATHWAYS; NADPH OXIDASES; GASDERMIN D;

D O I：

10.3389/fonc.2022.862743

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Redox homeostasis is a lifelong pursuit of cancer cells. Depending on the context, reactive oxygen species (ROS) exert paradoxical effects on cancers; an appropriate concentration stimulates tumorigenesis and supports the progression of cancer cells, while an excessive concentration leads to cell death. The upregulated antioxidant system in cancer cells limits ROS to a tumor-promoting level. In cancers, redox regulation interacts with tumor initiation, proliferation, metastasis, programmed cell death, autophagy, metabolic reprogramming, the tumor microenvironment, therapies, and therapeutic resistance to facilitate cancer development. This review discusses redox control and the major hallmarks of cancer.

引用

页数：21

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