Heme Oxygenase-1 Promotes Delayed Wound Healing in Diabetic Rats

被引：62
作者：
Chen, Qing-Ying [1 ]
Wang, Guo-Guang [2 ]
Li, Wei [2 ]
Jiang, Yu-Xin [3 ]
Lu, Xiao-Hua [2 ]
Zhou, Ping-Ping [3 ]
机构：
[1] Jinan Mil Command, Gen Hosp, Dept Med, 25 Shifan Rd, Jinan 250031, Shandong, Peoples R China
[2] Wannan Med Coll, Dept Pathophysiol, Wuhu 241002, Peoples R China
[3] Wannan Med Coll, Dept Physiol, Wuhu 241002, Peoples R China
来源：
JOURNAL OF DIABETES RESEARCH | 2016年 / 2016卷
基金：
中国国家自然科学基金;
关键词：
HYDROGEN-SULFIDE PROTECTS; THROMBOXANE RECEPTOR; OXIDATIVE STRESS; CARDIOVASCULAR-DISEASE; SYNTHASE INHIBITOR; NITRIC-OXIDE; SUPPLEMENTATION; ANGIOGENESIS; EXPRESSION; CELLS;
D O I：
10.1155/2016/9726503
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Diabetic ulcers are one of the most serious and costly chronic complications for diabetic patients. Hyperglycemia-induced oxidative stress may play an important role in diabetes and its complications. The aim of the study was to explore the effect of heme oxygenase-1 on wound closure in diabetic rats. Diabetic wound model was prepared by making an incision with full thickness in STZ-induced diabetic rats. Wounds from diabetic rats were treated with 10% hemin ointment for 21 days. Increase of HO-1 protein expression enhanced anti-inflammation and antioxidant in diabetic rats. Furthermore, HO-1 increased the levels of VEGF and ICAM-1 and expressions of CBS and CSE protein. In summary, HO-1 promoted the wound closure by augmenting anti-inflammation, antioxidant, and angiogenesis in diabetic rats.
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页数：10
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