Should we prescribe anticonvulsants for acute herpes zoster neuralgia and to prevent postherpetic neuralgia? A protocol for meta-analysis and benefit-risk assessment

被引:5
作者
Lu, Yanqing [1 ,2 ]
Liu, Kun [2 ]
Liang, Yanchang [3 ]
Zhang, Xi [4 ]
Liu, Yue [2 ]
Huang, Fan [2 ]
Gao, Haili [2 ]
Zhuang, Lixing [1 ,5 ]
机构
[1] Guangzhou Univ Tradit Chinese Med, Guangzhou, Guangdong, Peoples R China
[2] Guangzhou Univ Tradit Chinese Med, Clin Med Coll 5, Guangzhou, Guangdong, Peoples R China
[3] Guangzhou Univ Tradit Chinese Med, Sports & Hlth Inst, Guangzhou, Guangdong, Peoples R China
[4] Guangzhou Hosp Tradit Chinese Med, Neurosurg Dept, Guangzhou, Guangdong, Peoples R China
[5] Guangzhou Univ Tradit Chinese Med, Acupuncture Dept, Affiliated Hosp 1, 12 Airport Rd, Guangzhou 510405, Guangdong, Peoples R China
关键词
acute herpes zoster neuralgia; anticonvulsants; postherpetic neuralgia; RECOMMENDATIONS ASSESSMENT; PULSED RADIOFREQUENCY; SYSTEMATIC REVIEWS; EVALUATION GRADE; PAIN; MANAGEMENT; GABAPENTIN; HETEROGENEITY; STIMULATION; CONSUMPTION;
D O I
10.1097/MD.0000000000024343
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Herpes zoster-associated pain [i.e., acute herpes zoster neuralgia (AHN) and postherpetic neuralgia (PHN)] has the potential to cause significant patients' burden and heath resource expenditure. PHN is refractory to the existing treatments, and the consensus is preventing the transition of AHN to PHN is better than treating PHN. Anticonvulsants (e.g., gabapentin, pregabalin) have been recommended as one of the first-line therapies for PHN. In practice, anticonvulsants have also decreased the severity and duration of AHN and reduced the incidence of PHN. Nevertheless, its clinical application to AHN is hampered by inadequate evidence for its efficacy and safety. We performed this protocol for a systematic review to explore the efficacy and safety of anticonvulsants for AHN. Besides, a benefit-risk assessment of anticonvulsants for AHN would be performed to estimate the extent to which these drugs could relieve symptoms and whether the benefits outweigh harms. Methods: The Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols (PRISMA-P) was used to prepare our protocol and the results will be reported according to the PRISMA. We will search the China National Knowledge Infrastructure (CNKI), Chinese VIP Information (VIP), Cochrane Library, Embase, and PubMed databases, from inception to August 2019. Furthermore, Clinicaltrials (http://www.clinicaltrials.com) and Chinese Clinical Trial Registry (http://www.chictr.org.cn/abouten.aspx) will also be searched for relevant studies. Selection of eligible articles and data extraction will be independently performed by reviewers. We will record the characteristic information, pain outcomes, incidence of PHN and adverse effects. Data synthesis and other statistical analyses will be conducted using Review Manager Software 5.3 and STATA13.0. Furthermore, risk of bias assessment, meta-regression and subgroup analyses, publication bias assessment, grading of evidence will be performed for included studies. Ethics and dissemination: As this systematic review will be performed based on published data, no ethical approval is needed. The findings will be submitted in peer-reviewed journals for publication.
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页数:5
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