Oxidation of NADH and ROS production by respiratory complex I

被引：118
|
作者：
Vinogradov, Andrei D. [1 ]
Grivennikova, Vera G. [1 ]
机构：
[1] Moscow MV Lomonosov State Univ, Sch Biol, Dept Biochem, Moscow 119991, Russia
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 2016年 / 1857卷 / 07期
关键词：
NADH:quinone oxidoreductase; Proton pumping; Hydrogen peroxide; Superoxide; Bacterial plasma membranes; Mitochondria; UBIQUINONE OXIDOREDUCTASE COMPLEX; BOVINE HEART-MITOCHONDRIA; NICOTINAMIDE-ADENINE-DINUCLEOTIDE; STEADY-STATE KINETICS; HYDROGEN-PEROXIDE PRODUCTION; ACTIVE/DE-ACTIVE TRANSITION; ESCHERICHIA-COLI; SUBMITOCHONDRIAL PARTICLES; THERMUS-THERMOPHILUS; YARROWIA-LIPOLYTICA;
D O I：
10.1016/j.bbabio.2015.11.004
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Kinetic characteristics of the proton-pumping NADH:quinone reductases (respiratory complexes I) are reviewed. Unsolved problems of the redox-linked proton translocation activities are outlined. The parameters of complex I-mediated superoxide/hydrogen peroxide generation are summarized, and the physiological significance of mitochondrial ROS production is discussed. This article is part of a Special Issue entitled Respiratory complex I, edited by Volker Zickermann and Ulrich Brandt. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码：863 / 871
页数：9
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