Inflammatory Myofibroblastic Tumor of the Conjunctiva: Response to Chemotherapy With Low-Dose Methotrexate and Vinorelbine

被引:21
作者
Favini, Francesca [1 ]
Resti, Antonio Giordano [2 ]
Collini, Paola [3 ]
Casanova, Michela [1 ]
Meazza, Cristina [1 ]
Trecate, Giovanna [4 ]
Ferrari, Andrea [1 ]
机构
[1] Fdn IRCCS Ist Nazl Tumori, Pediat Oncol Unit, I-20133 Milan, Italy
[2] San Raffaele Hosp & Sci Inst, Ophthalmoplast Surg Unit, Dept Ophthalmol, Milan, Italy
[3] Fdn IRCCS Ist Nazl Tumori, Dept Pathol, I-20133 Milan, Italy
[4] Fdn IRCCS Ist Nazl Tumori, Dept Radiol, I-20133 Milan, Italy
关键词
conjunctiva; inflammatory myofibroblastic tumor; low-dose methotrexate; response to chemotherapy; vinorelbine; PSEUDOTUMOR; FIBROSARCOMA; EXPRESSION; CHILDREN; LUNG;
D O I
10.1002/pbc.22342
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Inflammatory myofibroblastic tumor (IMT) is an Unusual entity that mainly affects children and young adults, and for which standardized therapies for inoperable cases are still lacking. We report on a 12-year-old patient with an extremely rare and inoperable conjunctival location that was treated with chemotherapy using low-dose methotrexate plus vinorelbine, achieving complete tumor remission. This regimen is usually well tolerated and may be considered as the treatment of choice for cases of unresectable advanced IMT. Pediatr Blood Cancer 2010;54:483-485. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码:483 / 485
页数:3
相关论文
共 20 条
[1]  
Azzarelli A, 2001, CANCER, V92, P1259, DOI 10.1002/1097-0142(20010901)92:5<1259::AID-CNCR1446>3.0.CO
[2]  
2-Y
[3]   Inflammatory myofibroblastic tumor - Comparison of clinicopathologic, histologic, and immunohistochemical features including ALK expression in atypical and aggressive cases [J].
Coffin, Cheryl M. ;
Hornick, Jason L. ;
Fletcher, Christopher D. M. .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 2007, 31 (04) :509-520
[4]  
Coffin CM, 1998, SEMIN DIAGN PATHOL, V15, P102
[5]   ALK1 and p80 expression and chromosomal rearrangements involving 2p23 in inflammatory myofibroblastic tumor [J].
Coffin, CM ;
Patel, A ;
Perkins, S ;
Elenitoba-Johnson, KSJ ;
Perlman, E ;
Griffin, CA .
MODERN PATHOLOGY, 2001, 14 (06) :569-576
[6]   EXTRAPULMONARY INFLAMMATORY MYOFIBROBLASTIC TUMOR (INFLAMMATORY PSEUDOTUMOR) - A CLINICOPATHOLOGICAL AND IMMUNOHISTOCHEMICAL STUDY OF 84 CASES [J].
COFFIN, CM ;
WATTERSON, J ;
PRIEST, JR ;
DEHNER, LP .
AMERICAN JOURNAL OF SURGICAL PATHOLOGY, 1995, 19 (08) :859-872
[7]   Successful treatment of inflammatory myofibroblastic tumor with malignant transformation by surgical resection and chemotherapy [J].
Dishop, MK ;
Warner, BW ;
Dehner, LP ;
Kriss, VM ;
Greenwood, MF ;
Geil, JD ;
Moscow, JA .
JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY, 2003, 25 (02) :153-158
[8]   CORTICOSTEROIDS IN THE MANAGEMENT OF UNRESECTED PLASMA-CELL GRANULOMA (INFLAMMATORY PSEUDOTUMOR) OF THE LUNG [J].
DOSKI, JJ ;
PRIEBE, CJ ;
DRIESSNACK, M ;
SMITH, T ;
KANE, P ;
ROMERO, J .
JOURNAL OF PEDIATRIC SURGERY, 1991, 26 (09) :1064-1066
[9]  
Fletcher C DM., 2002, World Health Organisation Classification of tumours: Tumours of Soft Tissue and Bone, V3rd
[10]   A clinicopathologic case report of inflammatory pseudotumors involving the conjunctiva and lung [J].
Goto, Y ;
Ohaki, Y ;
Ibaraki, N .
JAPANESE JOURNAL OF OPHTHALMOLOGY, 2004, 48 (06) :573-577