Synthesis of 3,4-dihydropyrimidin-2(1H)-ones and 1,4-dihydropyridines using ammonium carbonate in water

被引：143
|
作者：
Tamaddon, Fatemeh [1 ]
Rami, Zahra [1 ]
Jafari, Abbas Ali [1 ]
机构：
[1] Yazd Univ, Fac Sci, Dept Chem, Yazd 89195741, Iran
来源：
TETRAHEDRON LETTERS | 2010年 / 51卷 / 08期
关键词：
Hantzsch reaction; Biginelli reaction; 1,4-Dihydropyridines; 3,4-Dihydropyrimidine-2(1H)-ones; (NH(4))(2)CO(3); ONE-POT SYNTHESIS; SOLVENT-FREE CONDITIONS; BIGINELLI REACTION; DIHYDROPYRIMIDINONES; OXIDATION; EFFICIENT; CATALYST; TRIPHENYLPHOSPHINE;
D O I：
10.1016/j.tetlet.2009.12.098
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Various known and new 3,4-dihydropyrimidin-2(1H)-ones and 1,4-dihydropyridines are prepared efficiently via Biginelli and Hantzsch reactions using ammonium carbonate in water. Competition between Biginelli and Hantzsch reactions is observed with pyridine carbaldehydes. Using this methodology, Hantzsch esters are synthesized in higher yields and purities than with other procedures without the use of a catalyst or an organic solvent. (C) 2009 Elsevier Ltd. All rights reserved.
引用
收藏
页码：1187 / 1189
页数：3
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