The brain-derived neurotrophic factor val66met polymorphism and variation in human cortical morphology

被引：709

作者：

Pezawas, L ^{[1
]}

Verchinski, BA ^{[1
]}

Mattay, VS ^{[1
]}

Callicott, JH ^{[1
]}

Kolachana, BS ^{[1
]}

Straub, RE ^{[1
]}

Egan, MF ^{[1
]}

Meyer-Lindenberg, A ^{[1
]}

Weinberger, DR ^{[1
]}

机构：

[1] NIMH, Genes Cognit & Psychosis Program, Intramural Res Program, NIH, Bethesda, MD 20892 USA

来源：

JOURNAL OF NEUROSCIENCE | 2004年 / 24卷 / 45期

关键词：

Alzheimer; Down syndrome; gene; Huntington; memory; morphometry; neurotrophic; schizophrenia; BDNF; voxel-based; VBM; imaging genomics;

D O I：

10.1523/JNEUROSCI.2680-04.2004

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A variation in the BDNF gene ( val66met) affects the function of BDNF in neurons, predicts variation in human memory, and is associated several neurological and psychiatric disorders. Here, we show that, in magnetic resonance imaging scans of a large sample of normal this polymorphism affects the anatomy of the hippocampus and prefrontal cortex, identifying a genetic mechanism of in brain morphology related to learning and memory.

引用

页码：10099 / 10102

页数：4

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