Porcine reproductive and respiratory syndrome

被引:456
作者
Rossow, KD [1 ]
机构
[1] S Dakota State Univ, Dept Vet Sci, S Dakota Anim Dis Res & Diagnost Lab, Brookings, SD 57007 USA
关键词
abortion; encephalitis; lymphadenopathy; myocarditis; persistence; pig; pneumonia; porcine reproductive and respiratory syndrome; semen; vasculitis;
D O I
10.1177/030098589803500101
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
In 1987, porcine reproductive and respiratory syndrome (PRRS) was recognized in the USA as a new disease of swine causing late-term reproductive failure and severe pneumonia in neonatal pigs. The syndrome is caused by an RNA virus referred to as PRRS virus (PRRSV), which is classified in the family Arteriviridae. Swine macrophages are the only indigenous cell type known to support PRRSV replication. Direct contact between infected and naive pigs is the predominant route of PRRSV transmission. Exposure of a mucosal surface to PRRSV leads to virus replication in regional macrophages, a prolonged viremia and systemic distribution of virus to other macrophage populations. Reproductive failure induced by PRRSV infection in late-gestation sows is characterized by premature farrowing of stillborn, partially autolyzed, and mummified fetuses. Pneumonia caused by PRRSV infection is more severe in young pigs compared to adults and may be complicated by concurrent bacterial infections. Gross lung lesions associated with PRRSV infection vary from none to diffuse consolidation. In addition, multiple lymph nodes may be markedly enlarged. Microscopically, PRRSV-pneumonia is characterized by multifocal, interstitial thickening by macrophages and necrotic cell debris in alveoli. Other less common microscopic lesions of PRRSV infection include myocarditis, vasculitis, encephalitis, and lymphoid hypertrophy and hyperplasia. In acute or subacute PRRSV infections, serum and lung are the best specimens for diagnosis. Persistent PRRSV infections can be produced by transplacental or intranasal infection. Persistent PRRSV infections are an important factor for virus survival and transmission within a swine herd and will complicate control programs.
引用
收藏
页码:1 / 20
页数:20
相关论文
共 50 条
  • [41] Pathological Characterization of an Outbreak of Porcine Reproductive and Respiratory Syndrome in Northern Vietnam
    Giang, N. T. Huong
    Lan, N. T.
    Nam, N. H.
    Hirai, T.
    Yamaguchi, R.
    JOURNAL OF COMPARATIVE PATHOLOGY, 2016, 154 (2-3) : 135 - 149
  • [42] A review of evidence for immunosuppression due to porcine reproductive and respiratory syndrome virus
    Drew, TW
    VETERINARY RESEARCH, 2000, 31 (01) : 27 - 39
  • [43] Persistence of porcine reproductive and respiratory syndrome virus and porcine circovirus type 2 in bacterial biofilms
    Jacques, Mario
    Grenier, Daniel
    Labrie, Josee
    Provost, Chantale
    Gagnon, Carl A.
    JOURNAL OF SWINE HEALTH AND PRODUCTION, 2015, 23 (03): : 132 - 136
  • [44] Fresh Pork and Porcine Reproductive and Respiratory Syndrome Virus: Factors Related to the Risk of Disease Transmission
    Hall, W.
    Neumann, E.
    TRANSBOUNDARY AND EMERGING DISEASES, 2015, 62 (04) : 350 - 366
  • [45] Proliferative vasculopathy and cutaneous hemorrhages in porcine neonates infected with the porcine reproductive and respiratory syndrome virus
    Scruggs, DW
    Sorden, SD
    VETERINARY PATHOLOGY, 2001, 38 (03) : 339 - 342
  • [46] Detection of porcine reproductive and respiratory syndrome virus in the ovary of gilts culled due to reproductive disturbances
    Tummaruk P.
    Phoophitphong D.
    Olanratmanee E.-O.
    Thanawongnuwech R.
    Comparative Clinical Pathology, 2015, 24 (4) : 903 - 910
  • [47] Genetic analysis of reproductive performance in sows during porcine reproductive and respiratory syndrome (PRRS) and porcine epidemic diarrhea (PED) outbreaks
    Cassandra L. Scanlan
    Austin M. Putz
    Kent A. Gray
    Nick V. L. Serão
    Journal of Animal Science and Biotechnology, 10
  • [48] Genetic analysis of reproductive performance in sows during porcine reproductive and respiratory syndrome(PRRS) and porcine epidemic diarrhea(PED)outbreaks
    Cassandra L.Scanlan
    Austin M.Putz
    Kent A.Gray
    Nick V.L.Ser?o
    JournalofAnimalScienceandBiotechnology, 2019, 10 (02) : 327 - 338
  • [49] Genetic analysis of reproductive performance in sows during porcine reproductive and respiratory syndrome (PRRS) and porcine epidemic diarrhea (PED) outbreaks
    Scanlan, Cassandra L.
    Putz, Austin M.
    Gray, Kent A.
    Serao, Nick V. L.
    JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 2019, 10 (1)
  • [50] Fetal Metabolomic Alterations Following Porcine Reproductive and Respiratory Syndrome Virus Infection
    Malgarin, Carolina M.
    MacPhee, Daniel J.
    Harding, John C. S.
    FRONTIERS IN MOLECULAR BIOSCIENCES, 2020, 7