Selective Vulnerability Related to Aging in Large-Scale Resting Brain Networks

被引:40
作者
Zhang, Hong-Ying [1 ]
Chen, Wen-Xin [1 ]
Jiao, Yun [2 ]
Xu, Yao [3 ]
Zhang, Xiang-Rong [4 ]
Wu, Jing-Tao [1 ]
机构
[1] Yangzhou Univ, Subei Peoples Hosp Jiangsu Prov, Dept Radiol, Yangzhou, Peoples R China
[2] Southeast Univ, Jiangsu Key Lab Mol & Funct Imaging, Nanjing, Jiangsu, Peoples R China
[3] Yangzhou Univ, Subei Peoples Hosp Jiangsu Prov, Dept Neurol, Yangzhou, Peoples R China
[4] Southeast Univ, Zhongda Hosp, Dept Psychiat, Nanjing, Jiangsu, Peoples R China
基金
中国国家自然科学基金;
关键词
AGE-RELATED-CHANGES; INTRINSIC CONNECTIVITY NETWORKS; DEFAULT-MODE NETWORK; FUNCTIONAL CONNECTIVITY; WORKING-MEMORY; HEMISPHERIC-ASYMMETRY; NEURAL ACTIVITY; MOTOR CORTEX; OLDER-ADULTS; PATTERNS;
D O I
10.1371/journal.pone.0108807
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Normal aging is associated with cognitive decline. Evidence indicates that large-scale brain networks are affected by aging; however, it has not been established whether aging has equivalent effects on specific large-scale networks. In the present study, 40 healthy subjects including 22 older (aged 60-80 years) and 18 younger (aged 22-33 years) adults underwent resting-state functional MRI scanning. Four canonical resting-state networks, including the default mode network (DMN), executive control network (ECN), dorsal attention network (DAN) and salience network, were extracted, and the functional connectivities in these canonical networks were compared between the younger and older groups. We found distinct, disruptive alterations present in the large-scale aging-related resting brain networks: the ECN was affected the most, followed by the DAN. However, the DMN and salience networks showed limited functional connectivity disruption. The visual network served as a control and was similarly preserved in both groups. Our findings suggest that the aged brain is characterized by selective vulnerability in large-scale brain networks. These results could help improve our understanding of the mechanism of degeneration in the aging brain. Additional work is warranted to determine whether selective alterations in the intrinsic networks are related to impairments in behavioral performance.
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页数:8
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