Association between TLR2, MTR, MTRR, XPC, TP73, TP53 genetic polymorphisms and gastric cancer: A meta-analysis

被引：22
作者：
Chen Cheng [1 ,2 ]
Wang Lingyan [3 ]
Huang Yi [4 ]
Zhang Cheng [1 ]
Ye Huadan [1 ]
Xu Xuting [1 ]
Xu Leiting [1 ]
Ye Meng [2 ]
Duan Shiwei [1 ]
机构：
[1] Ningbo Univ, Sch Med, Zhejiang Prov Key Lab Pathophysiol, Ningbo 315211, Zhejiang, Peoples R China
[2] Ningbo Univ, Affiliated Hosp, Ningbo 315000, Zhejiang, Peoples R China
[3] Ningbo 2 Hosp, Bank Blood Prod, Ningbo 315010, Zhejiang, Peoples R China
[4] Ningbo Univ, Ningbo Hosp 2, Dept Neurosurg, Ningbo 315010, Zhejiang, Peoples R China
来源：
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY | 2014年 / 38卷 / 03期
基金：
中国国家自然科学基金;
关键词：
CODON; 72; POLYMORPHISM; HELICOBACTER-PYLORI INFECTION; SINGLE-NUCLEOTIDE POLYMORPHISMS; P53 ARG72PRO POLYMORPHISMS; DNA-REPAIR; RECEPTOR; COLORECTAL-CANCER; NO ASSOCIATIONS; STOMACH-CANCER; RESPONSE GENES;
D O I：
10.1016/j.clinre.2013.12.009
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Objective: The aim of our meta-analyses is to test the association between six genetic polymorphisms and gastric cancer. Methods: A systematic search was performed for all the available candidate genes and gastric cancer among several online databases including PubMed, Embase, Web of Science, the Cochrane Library, CNKI and Wanfang online libraries. After a comprehensive screening, a total of six genes were harvested for the current meta-analyses. These genes include TLR2 (-196 to -174 ins>del), MTR (rs1805087), MTRR (rs1801394), XPC (rs2228001), TP73 (G4C14-A4T14), and TP53 (rs1042522). Results: Altogether 49 comparative studies among 11 776 cases and 18 633 controls were involved in our meta-analyses. TP53 rs1042522 polymorphism was shown to be associated with gastric cancer risk under the dominant model (P=0.02, OR = 1.03, 95% CI = 1.00-1.05). A subgroup meta-analysis indicated a significant association under dominant model between TP53 rs1042522 and gastric cancer in the Eastern Asians (P=0.03, OR=1.17, 95% = 1.02-1.34). Conclusions: These results suggest that TP53 rs1042522 polymorphism might contribute to the susceptibility of gastric cancer under the dominant model, especially in Eastern Asians. (C) 2014 Elsevier Masson SAS. All rights reserved.
引用
收藏
页码：346 / 359
页数：14
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