Prognostic value of the dynamics of M-type phospholipase A2 receptor antibody titers in patients with idiopathic membranous nephropathy treated with two different immunosuppression regimens

被引：20

作者：

Segarra Medrano, Alfonso ^{[1
]}

Jatem Escalante, Elias ^{[1
,2
]}

Carnicer Caceres, Clara ^{[2
]}

Agraz Pamplona, Irene ^{[1
]}

Salcedo Allende, Maria Teresa ^{[3
]}

Ramos Terrades, Natalia ^{[1
]}

Valtierra Carmeno, Naiara ^{[1
,2
]}

Ostos Roldan, Elena ^{[1
,2
]}

Arredondo Agudelo, Karla Viviana ^{[1
]}

Jaramillo Vasquez, Juliana ^{[1
]}

机构：

[1] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Dept Nephrol, E-08035 Barcelona, Spain

[2] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Dept Biochem, E-08035 Barcelona, Spain

[3] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Dept Pathol, E-08035 Barcelona, Spain

来源：

BIOMARKERS | 2015年 / 20卷 / 01期

关键词：

Cyclophospamide; membranous nephropathy; renal disease; rituximab; type M phospholipase A2 antibodies; RANDOMIZED CONTROLLED-TRIAL; CYCLOPHOSPHAMIDE; GLOMERULONEPHRITIS; AUTOANTIBODIES; CYCLOSPORINE; TACROLIMUS; OUTCOMES; THERAPY;

D O I：

10.3109/1354750X.2014.993708

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: The dynamics of anti-phospholipase A2 antibody titers during treatment could predict clinical responses in patients with membranous nephropathy. Objectives: We analyzed the predictive value of the dynamics of these antibodies on clinical responses. Materials and methods: The serum antibody levels were measured before and during treatment in 79 patients with anti-phospholipase A2 receptor antibody membranous nephropathy treated with two different immunosuppression regimens Results: In both groups of patients, the relative reduction in antibody titers at 3 and 6 months preceded and predicted the clinical responses. Conclusions: Antibody titer dynamics was useful for predicting clinical responses.

引用

页码：77 / 83

页数：7

共 26 条

[11]

Fulladosa X, 2007, NEFROLOGIA, V27, P70

[12]

Hofstra JM, 2012, NETH J MED, V70, P109

[13] Treatment of idiopathic membranous nephropathy [J].

Hofstra, Julia M. ;

Fervenza, Fernando C. ;

Wetzels, Jack F. M. .

NATURE REVIEWS NEPHROLOGY, 2013, 9 (08) :443-458

[14] Anti-Phospholipase A2 Receptor Antibodies Correlate with Clinical Status in Idiopathic Membranous Nephropathy [J].

Hofstra, Julia M. ;

Beck, Laurence H., Jr. ;

Beck, David M. ;

Wetzels, Jack F. ;

Salant, David J. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 6 (06) :1286-1291

[15] Early versus late start of immunosuppressive therapy in idiopathic membranous nephropathy: a randomized controlled trial [J].

Hofstra, Julia M. ;

Branten, Amanda J. W. ;

Wirtz, Joris J. J. M. ;

Noordzij, Ton C. ;

du Buf-Vereijken, Peggy W. G. ;

Wetzels, Jack F. M. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2010, 25 (01) :129-136

[16] Phospholipase A2 Receptor Autoantibodies and Clinical Outcome in Patients with Primary Membranous Nephropathy [J].

Hoxha, Elion ;

Thiele, Ina ;

Zahner, Gunther ;

Panzer, Ulf ;

Harendza, Sigrid ;

Stahl, Rolf A. K. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 25 (06) :1357-1366

[17] An immunofluorescence test for phospholipase-A2-receptor antibodies and its clinical usefulness in patients with membranous glomerulonephritis [J].

Hoxha, Elion ;

Harendza, Sigrid ;

Zahner, Gunter ;

Panzer, Ulf ;

Steinmetz, Oliver ;

Fechner, Kai ;

Helmchen, Udo ;

Stahl, Rolf A. K. .

NEPHROLOGY DIALYSIS TRANSPLANTATION, 2011, 26 (08) :2526-2532

[18] A randomized, controlled trial of steroids and cyclophosphamide in adults with nephrotic syndrome caused by idiopathic membranous nephropathy [J].

Jha, Vivekanand ;

Ganguli, Anirban ;

Saha, Tarun K. ;

Kohli, Harbir S. ;

Sud, Kamal ;

Gupta, Krishan L. ;

Joshi, Kusum ;

Sakhuja, Vinay .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2007, 18 (06) :1899-1904

[19] Anti-PLA2R antibodies measured by ELISA predict long-term outcome in a prevalent population of patients with idiopathic membranous nephropathy [J].

Kanigicherla, Durga ;

Gummadova, Jennet ;

McKenzie, Edward A. ;

Roberts, Stephen A. ;

Harris, Shelley ;

Nikam, Milind ;

Poulton, Kay ;

McWilliam, Lorna ;

Short, Colin D. ;

Venning, Michael ;

Brenchley, Paul E. .

KIDNEY INTERNATIONAL, 2013, 83 (05) :940-948

[20] Pathomechanisms and molecular basis of membranous glomerulopathy [J].

Kerjaschki, D .

LANCET, 2004, 364 (9441) :1194-1196

← 1 2 3 →