Prognostic value of the dynamics of M-type phospholipase A2 receptor antibody titers in patients with idiopathic membranous nephropathy treated with two different immunosuppression regimens

被引：20

作者：

Segarra Medrano, Alfonso ^{[1
]}

Jatem Escalante, Elias ^{[1
,2
]}

Carnicer Caceres, Clara ^{[2
]}

Agraz Pamplona, Irene ^{[1
]}

Salcedo Allende, Maria Teresa ^{[3
]}

Ramos Terrades, Natalia ^{[1
]}

Valtierra Carmeno, Naiara ^{[1
,2
]}

Ostos Roldan, Elena ^{[1
,2
]}

Arredondo Agudelo, Karla Viviana ^{[1
]}

Jaramillo Vasquez, Juliana ^{[1
]}

机构：

[1] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Dept Nephrol, E-08035 Barcelona, Spain

[2] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Dept Biochem, E-08035 Barcelona, Spain

[3] Autonomous Univ Barcelona, Vall dHebron Univ Hosp, Dept Pathol, E-08035 Barcelona, Spain

来源：

BIOMARKERS | 2015年 / 20卷 / 01期

关键词：

Cyclophospamide; membranous nephropathy; renal disease; rituximab; type M phospholipase A2 antibodies; RANDOMIZED CONTROLLED-TRIAL; CYCLOPHOSPHAMIDE; GLOMERULONEPHRITIS; AUTOANTIBODIES; CYCLOSPORINE; TACROLIMUS; OUTCOMES; THERAPY;

D O I：

10.3109/1354750X.2014.993708

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Context: The dynamics of anti-phospholipase A2 antibody titers during treatment could predict clinical responses in patients with membranous nephropathy. Objectives: We analyzed the predictive value of the dynamics of these antibodies on clinical responses. Materials and methods: The serum antibody levels were measured before and during treatment in 79 patients with anti-phospholipase A2 receptor antibody membranous nephropathy treated with two different immunosuppression regimens Results: In both groups of patients, the relative reduction in antibody titers at 3 and 6 months preceded and predicted the clinical responses. Conclusions: Antibody titer dynamics was useful for predicting clinical responses.

引用

页码：77 / 83

页数：7

共 26 条

[1]

[Anonymous], 2012, KIDNEY INT S, V2, P186

[2] Association of Anti-PLA2R Antibodies with Outcomes after Immunosuppressive Therapy in Idiopathic Membranous Nephropathy [J].

Bech, Anneke P. ;

Hofstra, Julia M. ;

Brenchley, Paul E. ;

Wetzels, Jack F. M. .

CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2014, 9 (08) :1386-1392

[3] Rituximab-Induced Depletion of Anti-PLA2R Autoantibodies Predicts Response in Membranous Nephropathy [J].

Beck, Laurence H., Jr. ;

Fervenza, Fernando C. ;

Beck, David M. ;

Bonegio, Ramon G. B. ;

Malik, Fahim A. ;

Erickson, Stephen B. ;

Cosio, Fernando G. ;

Cattran, Daniel C. ;

Salant, David J. .

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY, 2011, 22 (08) :1543-1550

[4] M-Type Phospholipase A(sub 2) Receptor as Target Antigen in Idiopathic Membranous Nephropathy. [J].

Beck, Laurence H., Jr. ;

Bonegio, Ramon G. B. ;

Lambeau, Gerard ;

Beck, David M. ;

Powell, David W. ;

Cummins, Timothy D. ;

Klein, Jon B. ;

Salant, David J. .

NEW ENGLAND JOURNAL OF MEDICINE, 2009, 361 (01) :11-21

[5] Antiphospholipase A2 Receptor Autoantibodies: A Comparison of Three Different Immunoassays for the Diagnosis of Idiopathic Membranous Nephropathy [J].

Behnert, Astrid ;

Schiffer, Mario ;

Mueller-Deile, Janina ;

Beck, Laurence H., Jr. ;

Mahler, Michael ;

Fritzler, Marvin J. .

JOURNAL OF IMMUNOLOGY RESEARCH, 2014, 2014

[6]

Caro J, 2014, NEPHROL DIAL TRANSPL

[7] A CONTROLLED TRIAL OF CYCLOSPORINE IN PATIENTS WITH PROGRESSIVE MEMBRANOUS NEPHROPATHY [J].

CATTRAN, DC ;

GREENWOOD, C ;

RITCHIE, S ;

BERNSTEIN, K ;

CHURCHILL, DN ;

CLARK, WF ;

MORRIN, PA ;

LAVOIE, S .

KIDNEY INTERNATIONAL, 1995, 47 (04) :1130-1135

[8] Cyclosporine in patients with steroid-resistant membranous nephropathy: A randomized trial [J].

Cattran, DC ;

Appel, GB ;

Hebert, LA ;

Hunsicker, LG ;

Pohl, MA ;

Hoy, WE ;

Maxwell, DR ;

Kunis, CL .

KIDNEY INTERNATIONAL, 2001, 59 (04) :1484-1490

[9] IDIOPATHIC MEMBRANOUS NEPHROPATHY - THE NATURAL-HISTORY OF UNTREATED PATIENTS [J].

DONADIO, JV ;

TORRES, VE ;

VELOSA, JA ;

WAGONER, RD ;

HOLLEY, KE ;

OKAMURA, M ;

ILSTRUP, DM ;

CHU, CP .

KIDNEY INTERNATIONAL, 1988, 33 (03) :708-715

[10] CONTROLLED TRIAL OF CYCLOPHOSPHAMIDE IN IDIOPATHIC MEMBRANOUS NEPHROPATHY [J].

DONADIO, JV ;

HOLLEY, KE ;

ANDERSON, CF ;

TAYLOR, WF .

KIDNEY INTERNATIONAL, 1974, 6 (06) :431-439

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