Chemical constituents of the Vietnamese liverwort Porella densifolia

被引：12
|
作者：
Dang Ngoc Quang [1 ,2 ]
Asakawa, Yoshinori [1 ]
机构：
[1] Tokushima Bunri Univ, Yamashiro, Tokushima 7708514, Japan
[2] Hanoi Univ Educ, Hanoi, Vietnam
来源：
FITOTERAPIA | 2010年 / 81卷 / 06期
基金：
日本学术振兴会;
关键词：
Porella densifolia; Liverwort; Nitric oxide; BRYOPHYTES; SESQUITERPENOIDS; CHEMOSYSTEMATICS; DITERPENOIDS;
D O I：
10.1016/j.fitote.2010.03.014
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
From the ether extract of Porella densifolia, the first liverwort collected and chemically investigated in Vietnam, a kaurane diterpenoid, ent-kauren-15-one (1) and two sesquiterpene norpinguisone (2) and norpinguisone methyl ester (3) have been purified. Their structures were elucidated by spectroscopic analysis. In addition, an X-ray crystal structure of norpinguisone was obtained, allowing to determine its stereochemistry. Furthermore, the inhibitory activity of nitric oxide (NO) production in RAW 264.7 cells stimulated by lipopolysaccharide (LPS) of compounds 1-3 was examined with their IC(50) values of 69.4, 45.5 and 1.68 mu M, respectively. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码：659 / 661
页数：3
相关论文
共 50 条
  • [1] ISOLATION OF 2 NEW ENT-KAURANE CLASS DITERPENOIDS FROM PORELLA-DENSIFOLIA (LIVERWORT)
    MATSUO, A
    UTO, S
    NAKAYAMA, M
    HAYASHI, S
    CHEMISTRY LETTERS, 1977, (04) : 327 - 330
  • [2] CHEMOSYSTEMATICS OF BRYOPHYTES .21. SESQUITERPENOIDS AND DITERPENOIDS FROM THE LIVERWORTS PORELLA-DENSIFOLIA SUBSP APPENDICULATA AND PORELLA-DENSIFOLIA VAR FALLAX
    ASAKAWA, Y
    TAKIKAWA, K
    TOYOTA, M
    UEDA, A
    TORI, M
    KUMAR, SS
    PHYTOCHEMISTRY, 1987, 26 (04) : 1019 - 1022
  • [3] NEW SESQUITERPENE ALCOHOL FROM PORELLA-VERNICOSA AND PORELLA-DENSIFOLIA (HEPATICA)
    ASAKAWA, Y
    TOYOTA, M
    ARATANI, T
    TETRAHEDRON LETTERS, 1976, (40) : 3619 - 3622
  • [4] Chemotaxonomy and cytotoxicity of the liverwort Porella Viridissima
    Metoyer, Benjamin
    Lebouvier, Nicolas
    Hnawia, Edouard
    Thouvenot, Louis
    Wang, Fengrui
    Rakotondraibe, Liva Harinantenaina
    Raharivelomanana, Phila
    Asakawa, Yoshinori
    Nour, Mohammed
    NATURAL PRODUCT RESEARCH, 2021, 35 (12) : 2099 - 2102
  • [5] Sesquiterpenoids from the liverwort Porella canariensis
    Cullmann, F
    Becker, H
    ZEITSCHRIFT FUR NATURFORSCHUNG SECTION C-A JOURNAL OF BIOSCIENCES, 1999, 54 (3-4): : 151 - 155
  • [6] Porella longifolia (Steph.) S.Hatt. and Porella densifolia var. robusta (Steph.) S.Hatt. (Porellaceae, Marchantiophyta) excluded from the liverwort flora of China
    Qian, Kai
    Bi, Xing-Feng
    Shu, Lei
    Zhu, Rui-Liang
    PHYTOTAXA, 2018, 350 (02) : 182 - 186
  • [7] The leafy liverwort Porella baueri (Porellaceae) is an allopolyploid
    Boisselier-Dubayle, MC
    Lambourdiere, J
    Bischler, H
    PLANT SYSTEMATICS AND EVOLUTION, 1998, 210 (3-4) : 175 - 197
  • [8] Pinguisane sesquiterpenes from the liverwort Porella navicularis
    Bungert, M
    Gabler, J
    Adam, KP
    Zapp, J
    Becker, H
    PHYTOCHEMISTRY, 1998, 49 (04) : 1079 - 1083
  • [9] Chemical constituents of the liverworts Bryopteris filicina, Plagiochila asplenioides and Porella canariensis
    Nagashima, F
    Matsumura, N
    Ashigaki, Y
    Asakawa, Y
    JOURNAL OF THE HATTORI BOTANICAL LABORATORY, 2003, (94): : 197 - 204
  • [10] TERPENOIDS OF THE LIVERWORT FRULLANOIDES-DENSIFOLIA AND TROCHOLEJEUNEA-SANDVICENSIS
    TORI, M
    ARBIYANTI, H
    TAIRA, Z
    ASAKAWA, Y
    PHYTOCHEMISTRY, 1993, 32 (02) : 335 - 348
12345