Risk Factors for Colorectal Cancer in Patients with Multiple Serrated Polyps: A Cross-Sectional Case Series from Genetics Clinics

被引：67

作者：

Buchanan, Daniel D. ^{[1
,2
]}

Sweet, Kevin ^{[3
]}

Drini, Musa ^{[4
]}

Jenkins, Mark A. ^{[5
]}

Win, Aung Ko ^{[5
]}

English, Dallas R. ^{[5
]}

Walsh, Michael D. ^{[1
,2
]}

Clendenning, Mark ^{[1
]}

McKeone, Diane M. ^{[1
]}

Walters, Rhiannon J. ^{[1
]}

Roberts, Aedan ^{[1
]}

Pearson, Sally-Ann ^{[1
]}

Pavluk, Erika ^{[1
]}

Hopper, John L. ^{[5
]}

Gattas, Michael R. ^{[6
]}

Goldblatt, Jack ^{[7
,8
]}

George, Jill ^{[8
]}

Suthers, Graeme K. ^{[9
,10
]}

Phillips, Kerry D. ^{[10
]}

Woodall, Sonja ^{[11
]}

Arnold, Julie ^{[11
]}

Tucker, Kathy ^{[12
]}

Muir, Amanda ^{[13
]}

Field, Michael ^{[13
]}

Greening, Sian ^{[14
]}

Gallinger, Steven ^{[15
,16
,17
]}

Perrier, Renee ^{[18
,19
]}

Baron, John A. ^{[20
]}

Potter, John D. ^{[21
]}

Haile, Robert ^{[22
]}

Frankel, Wendy ^{[3
]}

de la Chapelle, Albert ^{[3
]}

Macrae, Finlay ^{[23
]}

Rosty, Christophe ^{[1
,24
]}

Walker, Neal I. ^{[25
]}

Parry, Susan ^{[11
,26
]}

Young, Joanne P. ^{[1
,2
]}

机构：

[1] Queensland Inst Med Res, Familial Canc Lab, Herston, Qld, Australia

[2] Univ Queensland, Sch Med, Herston, Qld, Australia

[3] Ohio State Univ, Columbus, OH 43210 USA

[4] Canberra Hosp, Dept Gastroenterol & Hepatol, Garran, ACT, Australia

[5] Univ Melbourne, Sch Populat Hlth, Ctr MEGA Epidemiol, Carlton, Vic 3053, Australia

[6] Royal Childrens Hosp, Queensland Clin Genet Serv, Herston, Qld, Australia

[7] Univ Western Australia, Sch Paediat & Child Hlth, Nedlands, WA 6009, Australia

[8] Genet Serv Western Australia, Subiaco, WA, Australia

[9] Univ Adelaide, Dept Paediat, Adelaide, SA, Australia

[10] S Australian Clin Genet Serv, Adelaide, SA, Australia

[11] Auckland City Hosp, Familial GI Canc Registry, Auckland, New Zealand

[12] Prince Wales Hosp, Hereditary Canc Clin, Randwick, NSW 2031, Australia

[13] Royal N Shore Hosp, Dept Clin Genet, Sydney, NSW, Australia

[14] Wollongong Hosp, Illawarra Canc Ctr, Wollongong, NSW, Australia

[15] Mt Sinai Hosp, Samuel Lunenfeld Res Inst, Toronto, ON M5G 1X5, Canada

[16] Mt Sinai Hosp, D Zane Cohen Digest Dis Clin Res Ctr, Toronto, ON M5G 1X5, Canada

[17] Canc Care Ontario, Toronto, ON, Canada

[18] Univ British Columbia, Vancouver, BC V5Z 1M9, Canada

[19] BC Canc Agcy, Vancouver, BC, Canada

[20] Dartmouth Coll, Hitchcock Med Ctr, Dartmouth Med Sch, Dept Med, Hanover, NH 03756 USA

[21] Fred Hutchinson Canc Res Ctr, Canc Prevent Program, Seattle, WA 98104 USA

[22] Univ So Calif, USC Norris Comprehens Canc Ctr, Los Angeles, CA USA

[23] Royal Melbourne Hosp, Dept Colorectal Med & Genet, Parkville, Vic 3050, Australia

[24] Univ Queensland, Dept Mol & Cellular Pathol, Herston, Qld, Australia

[25] Envoi Pathol, Herston, Qld, Australia

[26] Middlemore Hosp, Dept Gastroenterol, Auckland 6, New Zealand

来源：

PLOS ONE | 2010年 / 5卷 / 07期

关键词：

ISLAND METHYLATOR PHENOTYPE; CIGARETTE-SMOKING; HYPERPLASTIC POLYPOSIS; BRAF MUTATIONS; LIFE-STYLE; MICROSATELLITE INSTABILITY; ADENOMATOUS POLYPOSIS; TOBACCO SMOKING; EARLY-ONSET; LONG-TERM;

D O I：

10.1371/journal.pone.0011636

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background: Patients with multiple serrated polyps are at an increased risk for developing colorectal cancer (CRC). Recent reports have linked cigarette smoking with the subset of CRC that develops from serrated polyps. The aim of this work therefore was to investigate the association between smoking and the risk of CRC in high-risk genetics clinic patients presenting with multiple serrated polyps. Methods and Findings: We identified 151 Caucasian individuals with multiple serrated polyps including at least 5 outside the rectum, and classified patients into non-smokers, current or former smokers at the time of initial diagnosis of polyposis. Cases were individuals with multiple serrated polyps who presented with CRC. Controls were individuals with multiple serrated polyps and no CRC. Multivariate logistic regression was performed to estimate associations between smoking and CRC with adjustment for age at first presentation, sex and co-existing traditional adenomas, a feature that has been consistently linked with CRC risk in patients with multiple serrated polyps. CRC was present in 56 (37%) individuals at presentation. Patients with at least one adenoma were 4 times more likely to present with CRC compared with patients without adenomas (OR = 4.09; 95% CI 1.27 to 13.14; P = 0.02). For females, the odds of CRC decreased by 90% in current smokers as compared to never smokers (OR = 0.10; 95% CI 0.02 to 0.47; P = 0.004) after adjusting for age and adenomas. For males, there was no relationship between current smoking and CRC. There was no statistical evidence of an association between former smoking and CRC for both sexes. Conclusion: A decreased odds for CRC was identified in females with multiple serrated polyps who currently smoke, independent of age and the presence of a traditional adenoma. Investigations into the biological basis for these observations could lead to non-smoking-related therapies being developed to decrease the risk of CRC and colectomy in these patients.

引用

页数：7

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