Neuronal growth-inhibitory factor (metallothionein-3): evaluation of the biological function of growth-inhibitory factor in the injured and neurodegenerative brain

被引：39
作者：
Howells, Claire [1 ]
West, Adrian K. [1 ]
Chung, Roger S. [1 ]
机构：
[1] Univ Tasmania, Menzies Res Inst, Hobart, Tas 7001, Australia
来源：
FEBS JOURNAL | 2010年 / 277卷 / 14期
基金：
澳大利亚研究理事会;
关键词：
brain injury; metals; neuronal growth-inhibitory factor (GIF); neurodegenerative disease; oxidative stress; ALZHEIMERS-DISEASE BRAIN; III MESSENGER-RNA; RAT-BRAIN; STAB WOUNDS; NEURITE FORMATION; CORTICAL-NEURONS; DOWN-REGULATION; MOUSE-BRAIN; EXPRESSION; ZINC;
D O I：
10.1111/j.1742-4658.2010.07718.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Neuronal growth-inhibitory factor, later renamed metallothionein-3, is one of four members of the mammalian metallothionein family. Metallothioneins are a family of ubiquitous, low-molecular-weight, cysteine-rich proteins. Although neuronal growth-inhibitory factor shares metal-binding and reactive oxygen species scavenging properties with the other metallothioneins, it displays several distinct biological properties. In this review, we examine the recent developments regarding the function of neuronal growth-inhibitory factor within the brain, particularly in response to brain injury or during neurodegenerative disease progression.
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收藏
页码：2931 / 2939
页数：9
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