Randomized placebo-controlled field study of the effects of bright light and melatonin in adaptation to night work

被引:63
作者
Bjorvatn, Bjorn
Stangenes, Kristine
Oyane, Nicolas
Forberg, Knut
Lowden, Arne
Holsten, Fred
Akerstedt, Torbjorn
机构
[1] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, N-5018 Bergen, Norway
[2] Univ Bergen, Dept Publ Hlth & Primary Hlth Care, Bergen, Norway
[3] Haukeland Hosp, Norwegian Competence Ctr Sleep Disorders, N-5021 Bergen, Norway
[4] Karolinska Inst, Natl Inst Psychosocial Med, IPM, Stockholm, Sweden
[5] Univ Bergen, Dept Psychiat, Bergen, Norway
关键词
circadian rhythm; objective ratings; shift work; subjective ratings;
D O I
10.5271/sjweh.1129
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Objectives This study evaluated the effects of bright light and melatonin on adaptation to night work on an oil rig in the North Sea. Methods Seventeen persons working a schedule of 2 weeks on a 12-hour shift, with the first week on night shift and the second week on day shift (ie, the swing shift schedule) participated. In a randomized controlled crossover design, the shift workers received a placebo, melatonin (3 mg, 1 hour before bedtime), or bright light (30-minute exposure, individually scheduled) during the first 4 days on the night shift and during the first 4 days on the day shift. Subjective and objective measures of sleepiness (Karolinska Sleepiness Scale and a simple serial reaction-time test) and sleep (diary and actigraphy) were recorded. Results Subjective measures indicated that melatonin modestly reduced sleepiness at work during the day shift and increased sleep by 15-20 minutes per day. Bright light gave values in between those of melatonin and the placebo, but with few significant results. According to the objective measures, bright light improved sleep to a minor degree during the night shift. Hardly any side-effects were reported. Conclusions Melatonin and bright light modestly improved sleep and sleepiness in this field study. In well-controlled simulated nightwork studies, both melatonin and bright light are more effective in alleviating sleepiness and sleep problems. The less effect in this field study may be due to competing or conflicting factors present in real life or to an inoptimal timing and duration of the treatments.
引用
收藏
页码:204 / 214
页数:11
相关论文
共 48 条
  • [1] PSYCHOLOGICAL AND PSYCHOPHYSIOLOGICAL EFFECTS OF SHIFT WORK
    AKERSTEDT, T
    [J]. SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH, 1990, 16 : 67 - 73
  • [2] Akerstedt T, 1998, Sleep Med Rev, V2, P117, DOI 10.1016/S1087-0792(98)90004-1
  • [3] Melatonin as a chronobiotic
    Arendt, J
    Skene, DJ
    [J]. SLEEP MEDICINE REVIEWS, 2005, 9 (01) : 25 - 39
  • [4] Intermittent bright light and exercise to entrain human circadian rhythms to night work
    Baehr, EK
    Fogg, LF
    Eastman, CI
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY, 1999, 277 (06) : R1598 - R1604
  • [5] Rapid adaptation to night work at an oil platform, but slow readaptation after returning home
    Bjorvatn, B
    Kecklund, G
    Akerstedt, T
    [J]. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE, 1998, 40 (07) : 601 - 608
  • [6] Bright light treatment used for adaptation to night work and re-adaptation back to day life.: A field study at an oil platform in the North Sea
    Bjorvatn, B
    Kecklund, G
    Åkerstedt, T
    [J]. JOURNAL OF SLEEP RESEARCH, 1999, 8 (02) : 105 - 112
  • [7] Subjective and objective measures of adaptation and readaptation to night work on an oil rig in the North Sea
    Bjorvatn, Bjorn
    Stangenes, Kristine
    Oyane, Nicolas
    Forberg, Knut
    Lowden, Arne
    Holsten, Fred
    Akerstedt, Torbjorn
    [J]. SLEEP, 2006, 29 (06) : 821 - 829
  • [8] Circadian adaptation to night-shift work by judicious light and darkness exposure
    Boivin, DB
    James, FO
    [J]. JOURNAL OF BIOLOGICAL RHYTHMS, 2002, 17 (06) : 556 - 567
  • [9] Effects of exogenous melatonin on sleep: a meta-analysis
    Brzezinski, A
    Vangel, MG
    Wurtman, RJ
    Norrie, G
    Zhdanova, I
    Ben-Shushan, A
    Ford, I
    [J]. SLEEP MEDICINE REVIEWS, 2005, 9 (01) : 41 - 50
  • [10] Bright light, dark and melatonin can promote circadian adaptation in night shift workers
    Burgess, HJ
    Sharkey, KM
    Eastman, CI
    [J]. SLEEP MEDICINE REVIEWS, 2002, 6 (05) : 407 - 420