Shortage of penicillin G: impact on antibiotic prescribing at a US tertiary care centre

被引：14

作者：

Harbarth, S ^{[1
]}

Gundlapalli, AV ^{[1
]}

Stockdale, W ^{[1
]}

Samore, MH ^{[1
]}

机构：

[1] Univ Utah, Sch Med, Div Infect Dis, Salt Lake City, UT USA

来源：

INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS | 2003年 / 21卷 / 05期

关键词：

penicillin G supply; antibiotics; drug industry; health policy; United States;

D O I：

10.1016/S0924-8579(03)00003-7

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

A six-year retrospective study was undertaken to examine the effect of the recent penicillin G (penG) shortage on antibiotic prescribing practices at a tertiary care centre in the US. Prior to the shortage, penG was predominantly used for intrapartum prophylaxis of group B streptococcal disease. As the supply of penG ended temporarily in October 1999, penG use declined dramatically, ampicillin replaced penG in obstetrics and a shift to broad-spectrum agents was noted in non-obstetric patients potentially eligible for penG treatment. Shortage-triggered treatment changes had a negative effect on prescribing patterns, which may contribute to antibiotic resistance. (C) 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.

引用

页码：484 / 487

页数：4

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