Incidence and prevalence of epilepsy and associated factors in a health district in North-West Cameroon: A population survey

被引:8
作者
Angwafor, Samuel A. [1 ]
Bell, Gail S. [1 ,2 ]
Ngarka, Leonard [3 ,4 ,6 ]
Otte, Willem [5 ,7 ,8 ]
Tabah, Earnest N. [9 ,10 ]
Nfor, Leonard N. [4 ,5 ,6 ]
Njamnshi, Theophilus N. [11 ]
Njamnshi, Alfred K. [4 ,5 ,6 ]
Sander, Josemir W. [1 ,2 ,12 ]
机构
[1] UCL Queen Sq Inst Neurol, NIHR Univ Coll London Hosp Biomed Res Ctr, London WC1N 3BG, England
[2] Chalfont Ctr Epilepsy, Gerrards Cross SL9 0RJ, Bucks, England
[3] Univ Bamenda, Fac Hlth Sci, Bamenda, Cameroon
[4] Univ Yaounde I, Fac Med & Biomed Sci FMBS, Cent Hosp Yaounde, Neurol Dept, Yaounde, Cameroon
[5] Brain Res Africa Initiat BRAIN, POB 25625, Yaounde, Cameroon
[6] Brain Res Africa Initiat BRAIN, Geneva, Switzerland
[7] Univ Med Ctr Utrecht, UMC Utrecht Brain Ctr, Dept Pediat Neurol, Utrecht, Netherlands
[8] Univ Utrecht, Utrecht, Netherlands
[9] Univ Dschang, Fac Med & Biomed Sci, Dept Publ Hlth, Dschang, Cameroon
[10] Minist Publ Hlth, Dept Dis Control, Yaounde, Cameroon
[11] Catholic Univ Cameroon, Sch Hlth & Med Sci, Dept Med Lab Sci, Bamenda, Cameroon
[12] Stichting Epilepsie Instelligen Nederland SEIN, Heemstede, Netherlands
关键词
Seizures; Epidemiology; Parasitic diseases; Risk factors; Batibo; ACTIVE CONVULSIVE EPILEPSY; DOOR-TO-DOOR; RISK-FACTORS; RURAL AREA; HYPERENDEMIC FOCUS; RETARDED GROWTH; ONCHOCERCIASIS; NEUROCYSTICERCOSIS; COMMUNITY; CYSTICERCOSIS;
D O I
10.1016/j.yebeh.2021.108048
中图分类号
B84 [心理学]; C [社会科学总论]; Q98 [人类学];
学科分类号
03 ; 0303 ; 030303 ; 04 ; 0402 ;
摘要
This population-based cross-sectional survey with a follow-up case-control study assessed the preva-lence, incidence, and risk factors for epilepsy in a rural health district in the North-West Region of Cameroon. Community-based epilepsy screening targeted all inhabitants, six years and older, in all 16 health areas in the Batibo Health District. During door-to-door visits, trained fieldworkers used a vali-dated questionnaire to interview consenting household heads to screen for epilepsy in eligible residents. Trained physicians subsequently assessed people with suspected seizures. After clinical assessment, they confirmed or refuted the diagnosis and estimated the date of epilepsy onset. A trained nurse interviewed people with epilepsy and randomly selected healthy individuals, obtaining relevant demographic details and information on exposure to risk factors for epilepsy. Out of 36,282 residents screened, 524 had active epilepsy. The age-standardized prevalence of active epilepsy was 33.9/1,000 (95% CI: 31.0-37.1/1,000). We estimated the one-year age-standardized epilepsy incidence at 171/100,000 (95%CI: 114.0-254.6). Active epilepsy prevalence varied widely between health areas, ranging between 12 and 75 per 1,000. The peak age-specific prevalence was in the 25-34 age group. In adults, multivariate analysis showed that having a relative with epilepsy was positively associated with epilepsy. Epilepsy characteristics in this population, geographical heterogeneity, and the age-specific prevalence pattern suggest that ende-mic neurocysticercosis and onchocerciasis may be implicated. Further investigations are warranted to establish the full range of risk factors for epilepsy in this population . (c) 2021 Elsevier Inc. All rights reserved.
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页数:11
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