Relationship between 2,5-hexanedione concentrations in nerve, serum, and urine alone or under co-treatment with different doses of methyl ethyl ketone, acetone, and toluene

被引：2

作者：

Zhao, WY ^{[1
]}

Misumi, J ^{[1
]}

Yasui, T ^{[1
]}

Aoki, K ^{[1
]}

Kimura, T ^{[1
]}

机构：

[1] Oita Med Univ, Dept Publ Hlth & Hyg, Oita 87955, Japan

来源：

NEUROCHEMICAL RESEARCH | 1998年 / 23卷 / 06期

关键词：

2,5-HD; co-treatment; correlation; serum; nerve; urine;

D O I：

10.1023/A:1022402810695

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

To ascertain the relationship among 2,5-hexanedione (2,5-HD) concentrations in nerve, serum and urine, rats were injected subcutaneously with 2.6 mmol/kg 2,5-HD alone, or together with 2.6 or 13.0 mmol/kg of methyl ethyl ketone, acetone and toluene. 2,5-HD concentrations in sciatic nerve (NC), serum (SC) and urine (UC) were determined, and the linear regression between each two of NC, SC, and UC were calculated. There was good correlation between NC and SC, SC and UC in the 2,5-HD alone group, and good correlation between NC and SC in the co-treated groups. Go-treatment solvent had little effect on the relationship between SC and NC. 13.0 mmol/kg cotreated solvent tended to decrease the regression coefficients compared with 2.6 mmol/kg co-heated solvent. These results show that SC can be used in estimating NC in the 2,5-HD alone or cotreated groups, and UC can be used in estimating SC in the 2,5-HD alone group.

引用

页码：837 / 843

页数：7