Prostate cancer cell heterogeneity and plasticity: Insights from studies of genetically-engineered mouse models

被引：7
作者：
Li, Weiping [1 ,2 ,3 ,4 ]
Shen, Michael M. [1 ,2 ,3 ,4 ]
机构：
[1] Columbia Univ, Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Dept Med, New York, NY 10032 USA
[2] Columbia Univ, Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Dept Genet & Dev, New York, NY 10032 USA
[3] Columbia Univ, Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Dept Urol, New York, NY 10032 USA
[4] Columbia Univ, Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Dept Syst Biol, New York, NY 10032 USA
来源：
SEMINARS IN CANCER BIOLOGY | 2022年 / 82卷
基金：
美国国家卫生研究院;
关键词：
Cell of origin; Cancer stem cell; Lineage plasticity; Castration-resistance; Genetically engineered mouse model; Tumor heterogeneity; TO-LUMINAL DIFFERENTIATION; EPITHELIAL STEM-CELL; ANDROGEN-RECEPTOR; BASAL-CELLS; NEUROENDOCRINE PHENOTYPE; LINEAGE PLASTICITY; PROGENITOR CELLS; OF-ORIGIN; RESISTANT; EXPRESSION;
D O I：
10.1016/j.semcancer.2021.06.016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although prostate adenocarcinoma lacks distinguishable histopathological subtypes, prostate cancer displays significant inter- and intratumor heterogeneity at the molecular level and with respect to disease prognosis and treatment response. In principle, understanding the basis for prostate cancer heterogeneity can help distinguish aggressive from indolent disease, and help overcome castration-resistance in advanced prostate cancer. In this review, we will discuss recent advances in understanding the cell types of origin, putative cancer stem cells, and tumor plasticity in prostate cancer, focusing on insights from studies of genetically engineered mouse models (GEMMs). We will also outline future directions for investigating tumor heterogeneity using mouse models of prostate cancer.
引用
收藏
页码：60 / 67
页数：8
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