Prostate cancer cell heterogeneity and plasticity: Insights from studies of genetically-engineered mouse models

被引：7
作者：
Li, Weiping [1 ,2 ,3 ,4 ]
Shen, Michael M. [1 ,2 ,3 ,4 ]
机构：
[1] Columbia Univ, Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Dept Med, New York, NY 10032 USA
[2] Columbia Univ, Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Dept Genet & Dev, New York, NY 10032 USA
[3] Columbia Univ, Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Dept Urol, New York, NY 10032 USA
[4] Columbia Univ, Coll Phys & Surg, Herbert Irving Comprehens Canc Ctr, Dept Syst Biol, New York, NY 10032 USA
来源：
SEMINARS IN CANCER BIOLOGY | 2022年 / 82卷
基金：
美国国家卫生研究院;
关键词：
Cell of origin; Cancer stem cell; Lineage plasticity; Castration-resistance; Genetically engineered mouse model; Tumor heterogeneity; TO-LUMINAL DIFFERENTIATION; EPITHELIAL STEM-CELL; ANDROGEN-RECEPTOR; BASAL-CELLS; NEUROENDOCRINE PHENOTYPE; LINEAGE PLASTICITY; PROGENITOR CELLS; OF-ORIGIN; RESISTANT; EXPRESSION;
D O I：
10.1016/j.semcancer.2021.06.016
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Although prostate adenocarcinoma lacks distinguishable histopathological subtypes, prostate cancer displays significant inter- and intratumor heterogeneity at the molecular level and with respect to disease prognosis and treatment response. In principle, understanding the basis for prostate cancer heterogeneity can help distinguish aggressive from indolent disease, and help overcome castration-resistance in advanced prostate cancer. In this review, we will discuss recent advances in understanding the cell types of origin, putative cancer stem cells, and tumor plasticity in prostate cancer, focusing on insights from studies of genetically engineered mouse models (GEMMs). We will also outline future directions for investigating tumor heterogeneity using mouse models of prostate cancer.
引用
收藏
页码：60 / 67
页数：8
相关论文
共 117 条
  • [1] The Molecular Taxonomy of Primary Prostate Cancer
    Abeshouse, Adam
    Ahn, Jaeil
    Akbani, Rehan
    Ally, Adrian
    Amin, Samirkumar
    Andry, Christopher D.
    Annala, Matti
    Aprikian, Armen
    Armenia, Joshua
    Arora, Arshi
    Auman, J. Todd
    Balasundaram, Miruna
    Balu, Saianand
    Barbieri, Christopher E.
    Bauer, Thomas
    Benz, Christopher C.
    Bergeron, Alain
    Beroukhim, Rameen
    Berrios, Mario
    Bivol, Adrian
    Bodenheimer, Tom
    Boice, Lori
    Bootwalla, Moiz S.
    dos Reis, Rodolfo Borges
    Boutros, Paul C.
    Bowen, Jay
    Bowlby, Reanne
    Boyd, Jeffrey
    Bradley, Robert K.
    Breggia, Anne
    Brimo, Fadi
    Bristow, Christopher A.
    Brooks, Denise
    Broom, Bradley M.
    Bryce, Alan H.
    Bubley, Glenn
    Burks, Eric
    Butterfield, Yaron S. N.
    Button, Michael
    Canes, David
    Carlotti, Carlos G.
    Carlsen, Rebecca
    Carmel, Michel
    Carroll, Peter R.
    Carter, Scott L.
    Cartun, Richard
    Carver, Brett S.
    Chan, June M.
    Chang, Matthew T.
    Chen, Yu
    [J]. CELL, 2015, 163 (04) : 1011 - 1025
  • [2] Genomic correlates of clinical outcome in advanced prostate cancer
    Abida, Wassim
    Cyrta, Joanna
    Heller, Glenn
    Prandi, Davide
    Armenia, Joshua
    Coleman, Ilsa
    Cieslik, Marcin
    Benelli, Matteo
    Robinson, Dan
    Van Allen, Eliezer M.
    Sboner, Andrea
    Fedrizzi, Tarcisio
    Mosquera, Juan Miguel
    Robinson, Brian D.
    De Sarkar, Navonil
    Kunju, Lakshmi P.
    Tomlins, Scott
    Wu, Yi Mi
    Rodrigues, Daniel Nava
    Loda, Massimo
    Gopalan, Anuradha
    Reuter, Victor E.
    Pritchard, Colin C.
    Mateo, Joaquin
    Bianchini, Diletta
    Miranda, Susana
    Carreira, Suzanne
    Rescigno, Pasquale
    Filipenko, Julie
    Vinson, Jacob
    Montgomery, Robert B.
    Beltran, Himisha
    Heath, Elisabeth I.
    Scher, Howard I.
    Kantoff, Philip W.
    Taplin, Mary-Ellen
    Schultz, Nikolaus
    deBono, Johann S.
    Demichelis, Francesca
    Nelson, Peter S.
    Rubin, Mark A.
    Chinnaiyan, Arul M.
    Sawyers, Charles L.
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2019, 116 (23) : 11428 - 11436
  • [3] Identification of Different Classes of Luminal Progenitor Cells within Prostate Tumors
    Agarwal, Supreet
    Hynes, Paul G.
    Tillman, Heather S.
    Lake, Ross
    Abou-Kheir, Wassim G.
    Fang, Lei
    Casey, Orla M.
    Ameri, Amir H.
    Martin, Philip L.
    Yin, Juan Juan
    Iaquinta, Phillip J.
    Karthaus, Wouter R.
    Clevers, Hans C.
    Sawyers, Charles L.
    Kelly, Kathleen
    [J]. CELL REPORTS, 2015, 13 (10): : 2147 - 2158
  • [4] Clinical and Genomic Characterization of Treatment-Emergent Small-Cell Neuroendocrine Prostate Cancer: A Multi-institutional Prospective Study
    Aggarwal, Rahul
    Huang, Jiaoti
    Alumkal, Joshi J.
    Zhang, Li
    Feng, Felix Y.
    Thomas, George V.
    Weinstein, Alana S.
    Friedl, Verena
    Zhang, Can
    Witte, Owen N.
    Lloyd, Paul
    Gleave, Martin
    Evans, Christopher P.
    Youngren, Jack
    Beer, Tomasz M.
    Rettig, Matthew
    Wong, Christopher K.
    True, Lawrence
    Foye, Adam
    Playdle, Denise
    Ryan, Charles J.
    Lara, Primo
    Chi, Kim N.
    Uzunangelov, Vlado
    Sokolov, Artem
    Newton, Yulia
    Beltran, Himisha
    Demichelis, Francesca
    Rubin, Mark A.
    Stuart, Joshua M.
    Small, Eric J.
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2018, 36 (24) : 2492 - +
  • [5] Punctuated Evolution of Prostate Cancer Genomes
    Baca, Sylvan C.
    Prandi, Davide
    Lawrence, Michael S.
    Mosquera, Juan Miguel
    Romanel, Alessandro
    Drier, Yotam
    Park, Kyung
    Kitabayashi, Naoki
    MacDonald, Theresa Y.
    Ghandi, Mahmoud
    Van Allen, Eliezer
    Kryukov, Gregory V.
    Sboner, Andrea
    Theurillat, Jean-Philippe
    Soong, T. David
    Nickerson, Elizabeth
    Auclair, Daniel
    Tewari, Ashutosh
    Beltran, Himisha
    Onofrio, Robert C.
    Boysen, Gunther
    Guiducci, Candace
    Barbieri, Christopher E.
    Cibulskis, Kristian
    Sivachenko, Andrey
    Carter, Scott L.
    Saksena, Gordon
    Voet, Douglas
    Ramos, Alex H.
    Winckler, Wendy
    Cipicchio, Michelle
    Ardlie, Kristin
    Kantoff, Philip W.
    Berger, Michael F.
    Gabriel, Stacey B.
    Golub, Todd R.
    Meyerson, Matthew
    Lander, Eric S.
    Elemento, Olivier
    Getz, Gad
    Demichelis, Francesca
    Rubin, Mark A.
    Garraway, Levi A.
    [J]. CELL, 2013, 153 (03) : 666 - 677
  • [6] Exome sequencing identifies recurrent SPOP, FOXA1 and MED12 mutations in prostate cancer
    Barbieri, Christopher E.
    Baca, Sylvan C.
    Lawrence, Michael S.
    Demichelis, Francesca
    Blattner, Mirjam
    Theurillat, Jean-Philippe
    White, Thomas A.
    Stojanov, Petar
    Van Allen, Eliezer
    Stransky, Nicolas
    Nickerson, Elizabeth
    Chae, Sung-Suk
    Boysen, Gunther
    Auclair, Daniel
    Onofrio, Robert C.
    Park, Kyung
    Kitabayashi, Naoki
    MacDonald, Theresa Y.
    Sheikh, Karen
    Vuong, Terry
    Guiducci, Candace
    Cibulskis, Kristian
    Sivachenko, Andrey
    Carter, Scott L.
    Saksena, Gordon
    Voet, Douglas
    Hussain, Wasay M.
    Ramos, Alex H.
    Winckler, Wendy
    Redman, Michelle C.
    Ardlie, Kristin
    Tewari, Ashutosh K.
    Mosquera, Juan Miguel
    Rupp, Niels
    Wild, Peter J.
    Moch, Holger
    Morrissey, Colm
    Nelson, Peter S.
    Kantoff, Philip W.
    Gabriel, Stacey B.
    Golub, Todd R.
    Meyerson, Matthew
    Lander, Eric S.
    Getz, Gad
    Rubin, Mark A.
    Garraway, Levi A.
    [J]. NATURE GENETICS, 2012, 44 (06) : 685 - U107
  • [7] Cancer stem cells revisited
    Batlle, Eduard
    Clevers, Hans
    [J]. NATURE MEDICINE, 2017, 23 (10) : 1124 - 1134
  • [8] The Role of Lineage Plasticity in Prostate Cancer Therapy Resistance
    Beltran, Himisha
    Hruszkewycz, Andrew
    Scher, Howard I.
    Hildesheim, Jeffrey
    Isaacs, Jennifer
    Yu, Evan Y.
    Kelly, Kathleen
    Lin, Daniel
    Dicker, Adam
    Arnold, Julia
    Hecht, Toby
    Wicha, Max
    Sears, Rosalie
    Rowley, David
    White, Richard
    Gulley, James L.
    Lee, John
    Meco, Maria Diaz
    Small, Eric J.
    Shen, Michael
    Knudsen, Karen
    Goodrich, David W.
    Lotan, Tamara
    Zoubeidi, Amina
    Sawyers, Charles L.
    Rudin, Charles M.
    Loda, Massimo
    Thompson, Timothy
    Rubin, Mark A.
    Tawab-Amiri, Abdul
    Dahut, William
    Nelson, Peter S.
    [J]. CLINICAL CANCER RESEARCH, 2019, 25 (23) : 6916 - 6924
  • [9] Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer
    Beltran, Himisha
    Prandi, Davide
    Mosquera, Juan Miguel
    Benelli, Matteo
    Puca, Loredana
    Cyrta, Joanna
    Marotz, Clarisse
    Giannopoulou, Eugenia
    Chakravarthi, Balabhadrapatruni V. S. K.
    Varambally, Sooryanarayana
    Tomlins, Scott A.
    Nanus, David M.
    Tagawa, Scott T.
    Van Allen, Eliezer M.
    Elemento, Olivier
    Sboner, Andrea
    Garraway, Levi A.
    Rubin, Mark A.
    Demichelis, Francesca
    [J]. NATURE MEDICINE, 2016, 22 (03) : 298 - 305
  • [10] Aggressive Variants of Castration-Resistant Prostate Cancer
    Beltran, Himisha
    Tomlins, Scott
    Aparicio, Ana
    Arora, Vivek
    Rickman, David
    Ayala, Gustavo
    Huang, Jiaoti
    True, Lawrence
    Gleave, Martin E.
    Soule, Howard
    Logothetis, Christopher
    Rubin, Mark A.
    [J]. CLINICAL CANCER RESEARCH, 2014, 20 (11) : 2846 - 2850
12345678910