Serum profiles of monocyte chemoattractant protein-1 as a biomarker for patients recovering from myocardial infarction

被引：5
作者：
Korybalska, Katarzyna [1 ]
Pyda, Malgorzata [2 ]
Grajek, Stefan [2 ]
Lanocha, Magdalena [2 ]
Breborowicz, Andrzej [1 ]
Witowski, Janusz [1 ]
机构：
[1] Poznan Univ Med Sci, Dept Pathophysiol, PL-60781 Poznan, Poland
[2] Poznan Univ Med Sci, Dept Cardiol 1, Poznan, Poland
来源：
CLINICAL RESEARCH IN CARDIOLOGY | 2010年 / 99卷 / 05期
关键词：
Monocyte chemoattractant protein-1; Acute coronary syndrome; Left ventricular function; Restenosis; ACUTE CORONARY SYNDROMES; ARTERY-DISEASE; PLASMA MCP-1; CARDIOVASCULAR RISK; GENE-EXPRESSION; CHEMOKINES; ATHEROSCLEROSIS; HYPOXIA; RESTENOSIS; INJURY;
D O I：
10.1007/s00392-010-0122-1
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Monocyte chemoattractant protein-1 (MCP-1) plays a key role in the pathogenesis of atherosclerosis and has been proposed as a biomarker for patients with cardiovascular disease. To assess its clinical usefulness, serum MCP-1 concentrations were measured in patients with ST-elevation myocardial infarction (MI) at admission, immediately after percutaneous coronary intervention (PCI), at 24 h, and after 6 months. We found no differences in MCP-1 concentrations between patients with acute MI, patients with stable coronary artery disease and healthy individuals. Although median MCP-1 concentrations in patients with MI were similar at admission and after 6 months, there were significant differences between individuals in how MCP-1 levels changed with time. As demonstrated by comparing baseline quartiles of MCP-1, the levels of MCP-1 tended to increase in patients with low MCP-1 concentration at admission, and decrease in patients with initially high MCP-1 levels. We found an inverse correlation between MCP-1 concentration at baseline and the time to reperfusion, and detected a significant decrease in MCP-1 concentration immediately after PCI. We also observed lower MCP-1 concentrations over time in patients who developed restenosis within 6 months. However, we did not confirm the association between MCP-1 concentrations at baseline and a number of previously implicated demographic, clinical and laboratory criteria. Our data demonstrate some new aspects of MCP-1 measurement in patients with MI, but do not corroborate many earlier observations.
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收藏
页码：315 / 322
页数：8
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[1]   Chemokines and Cardiovascular Risk [J].
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