Organocatalytic kinetic resolution via intramolecular aldol reactions: Enantioselective synthesis of both enantiomers of chiral cyclohexenones

被引：35

作者：

Chen, Liujuan ^{[1
]}

Luo, Sanzhong ^{[1
]}

Li, Jiuyuan ^{[1
]}

Li, Xin ^{[1
]}

Cheng, Jin-Pei ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Mol Recognit & Funct, Beijing 100190, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2010年 / 8卷 / 11期

关键词：

ASYMMETRIC DIRECT ALDOL; SAUER-WIECHERT REACTION; ALPHA; BETA-UNSATURATED KETONES; ROBINSON ANNULATION; CYCLOHEXANE RINGS; MICHAEL REACTIONS; AMINE CATALYSTS; ACID; EFFICIENT; 2-CYCLOHEXENONES;

D O I：

10.1039/b927343c

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Kinetic resolution of 6-aryl-2,6-hexanediones was achieved with chiral secondary amine catalyzed intramolecular aldolization. The current kinetic resolution protocol enables the synthesis of both enantiomers of cyclohexenones with moderate to good enantioselectivity.

引用

页码：2627 / 2632

页数：6

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