Size-controlled synthesis, characterization, and cytotoxicity study of monodisperse poly(dimethylsiloxane) nanoparticles

被引：15

作者：

Baipaywad, Phornsawat ^{[1
]}

Kim, Yunkyung ^{[1
]}

Wi, Jung-Sub ^{[2
]}

Paik, Taejong ^{[1
]}

Park, Hansoo ^{[1
]}

机构：

[1] Chung Ang Univ, Sch Integrat Engn, Seoul 156756, South Korea

[2] Korea Res Inst Stand & Sci, Ctr Nanobio Measurement, Daejeon, South Korea

来源：

JOURNAL OF INDUSTRIAL AND ENGINEERING CHEMISTRY | 2017年 / 53卷

基金：

新加坡国家研究基金会;

关键词：

Poly(dimethylsiloxane); Nanoparticles; Colloidal; Surface modification; Biomaterials; SILICA NANOPARTICLES; MESOPOROUS ORGANOSILICA; POLYDIMETHYLSILOXANE; HYBRIDIZATION; TOXICITY; DELIVERY; GROWTH;

D O I：

10.1016/j.jiec.2017.04.023

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polydimethylsiloxane (PDMS) nanoparticles (NPs) were synthesized using dimethylsiloxane and tetraethyl orthosilicate as precursors via a modified Stober process. A diluted ammonia solution was added to the reaction mixture. This induced base-catalyzed hydrolysis and condensation, forming dispersed nanocolloids. The as -synthesized organosilica NPs exhibited excellent colloidal stability without any noticeable precipitation in water. The particle size was readily tunable, in a diameter range of approximately 50-300 nm, by changing the amount of catalysts added to the reaction. Furthermore, we evaluated the cytotoxicity of PDMS NPs using a CCK-8 assay to demonstrate that PDMS NPs are promising for biomedical applications. (C) 2017 The Korean Society of Industrial and Engineering Chemistry. Published by Elsevier B.V. All rights reserved.

引用

页码：177 / 182

页数：6

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