Prognostic factors of primary resected retroperitoneal soft tissue sarcoma: Analysis from a single asian tertiary center and external validation of gronchi's nomogram

被引：32

作者：

Chou, Yi-Sheng ^{[1
,2
,3
,4
]}

Liu, Chun-Yu ^{[1
,2
]}

Chang, Yen-Hwa ^{[2
,5
,6
,7
]}

King, Kuang-Liang ^{[2
,8
]}

Chen, Paul Chih-Hsueh ^{[2
,9
]}

Pan, Chin-Chen ^{[2
,9
]}

Shen, Shu-Huei ^{[2
,10
]}

Liu, Yu-Ming ^{[2
,11
]}

Lin, Alex T. L. ^{[2
,5
]}

Chen, Kuang-Kuo ^{[2
,5
]}

Shyr, Yi-Ming ^{[2
,8
]}

Lee, Rheun-Chuan ^{[2
,10
]}

Chao, Ta-Chung ^{[1
,2
]}

Yang, Muh-Hwa ^{[1
,2
]}

Chan, Chung-Huang ^{[4
]}

You, Jie-Yu ^{[4
]}

Yen, Chueh-Chuan ^{[1
,2
,12
]}

机构：

[1] Taipei Vet Gen Hosp, Dept Oncol, Div Med Oncol, 201 Sec 2,Shih Pai Rd, Taipei 112, Taiwan

[2] Natl Yang Ming Univ, Sch Med, Taipei 112, Taiwan

[3] Natl Yang Ming Univ, Inst Clin Med, Taipei 112, Taiwan

[4] Lotung Poh Ai Hosp, Lo Hsu Fdn, Dept Med, Div Hematol & Oncol, Luodong, Yilan, Taiwan

[5] Taipei Vet Gen Hosp, Dept Urol, 201 Sec 2,Shih Pai Rd, Taipei 112, Taiwan

[6] Natl Yang Ming Univ, Dept Urol, Taipei 112, Taiwan

[7] Natl Yang Ming Univ, Shu Tien Urol Res Ctr, Taipei 112, Taiwan

[8] Taipei Vet Gen Hosp, Dept Surg, Div Gen Surg, 201 Sec 2,Shih Pai Rd, Taipei 112, Taiwan

[9] Taipei Vet Gen Hosp, Dept Pathol & Lab Med, 201 Sec 2,Shih Pai Rd, Taipei 112, Taiwan

[10] Taipei Vet Gen Hosp, Dept Radiol, 201 Sec 2,Shih Pai Rd, Taipei 112, Taiwan

[11] Taipei Vet Gen Hosp, Dept Oncol, 201 Sec 2,Shih Pai Rd, Taipei 112, Taiwan

[12] Taipei Vet Gen Hosp, Therapeut & Res Ctr Musculoskeletal Tumor, 201 Sec 2,Shih Pai Rd, Taipei 112, Taiwan

来源：

JOURNAL OF SURGICAL ONCOLOGY | 2016年 / 113卷 / 04期

基金：

奥地利科学基金会;

关键词：

retroperitoneal sarcoma; prognostic factor; nomogram; POPULATION-BASED-ANALYSIS; ADJUVANT CHEMOTHERAPY; MULTIVARIATE-ANALYSIS; RADIATION-THERAPY; SURVIVAL; SURGERY; RADIOTHERAPY; INSTITUTION; RECURRENCE; EXPERIENCE;

D O I：

10.1002/jso.24155

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

BackgroundSurgery is the potentially curative treatment for retroperitoneal sarcoma (RS), but complete resectability is frequently a challenge. This study aimed to characterize the clinical features, prognostic factors and treatment outcomes. MethodsA cohort of 144 patients with RS was surveyed retrospectively from January 1st, 2000 to July 30th, 2011. The prognostic influence of clinicopathological characteristics as well as treatments on local recurrence-free survival (LRFS), distant metastasis-free survival (DMFS), and overall survival (OS), were examined by univariate and multivariate analyses. A histology-specific nomogram developed by Gronchi et al was used for validation. ResultsLiposarcoma, leiomyosarcoma, and malignant peripheral sheath tumor (MPNST) were the most common histologies (70%). Multivariate analysis revealed FNCLCC tumor grade was the most significant prognostic factor for OS (P=0.001) and DMFS (P<0.001) and complete resection was the only significant prognostic factor for LRFS (P=0.043). Incomplete resection of grade 3 tumor was significantly associated with a worse OS. Despite some differences in characteristics between our patients and Gronchi's cohort, external validation of Gronchi's nomogram demonstrated excellent concordance in predicting survival. ConclusionsOur study demonstrated tumor grade and surgical margins had significant prognostic influence and the Gronchi's nomogram has an excellent applicability in predicting survival of STS patients. J. Surg. Oncol. 2016;113:355-360. (c) 2016 Wiley Periodicals, Inc.

引用

页码：355 / 360

页数：6

共 35 条

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