Expanding the Hoogsteen edge of 2′-deoxyguanosine:: Consequences for G-quadruplex formation

被引：60

作者：

Gubala, V ^{[1
]}

Betancourt, JE ^{[1
]}

Rivera, JM ^{[1
]}

机构：

[1] Univ Puerto Rico, Dept Chem, Rio Piedras, PR 00931 USA

来源：

ORGANIC LETTERS | 2004年 / 6卷 / 25期

关键词：

D O I：

10.1021/ol048013v

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis and self-assembling properties of 8-aryl-2'-deoxyguanosine derivatives are described. Our studies suggest that a properly placed acetyl group can increase the stability and specificity of the resulting G-quadruplex supramolecules by enhancing noncovalent interactions such as hydrogen bonds and z-stacking.

引用

页码：4735 / 4738

页数：4

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