The transcriptional interactome: gene expression in 3D

被引：120

作者：

Schoenfelder, Stefan ^{[1
]}

Clay, Ieuan ^{[1
]}

Fraser, Peter ^{[1
]}

机构：

[1] Babraham Inst, Lab Chromatin & Gene Express, Cambridge CB22 3AT, England

来源：

CURRENT OPINION IN GENETICS & DEVELOPMENT | 2010年 / 20卷 / 02期

基金：

英国生物技术与生命科学研究理事会; 英国医学研究理事会;

关键词：

BETA-GLOBIN LOCUS; MESSENGER-RNA; INTERCHROMOSOMAL ASSOCIATIONS; CHROMOSOME TERRITORIES; NUCLEAR-ORGANIZATION; SPATIAL-ORGANIZATION; COLORECTAL-CANCER; CONTROL REGION; CHROMATIN; RECEPTOR;

D O I：

10.1016/j.gde.2010.02.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Transcription in the eukaryotic nucleus has long been thought of as conforming to a model in which RNA polymerase complexes are recruited to and track along isolated templates. However, a more dynamic role for chromatin in transcriptional regulation is materializing: enhancer elements interact with promoters forming loops that often bridge considerable distances and genomic loci, even located on different chromosomes, undergo chromosomal associations. These associations amass to form an extensive 'transcriptional interactome', enacted at functional subnuclear compartments, to which genes dynamically relocate. The emerging view is that long-range chromosomal associations between genomic regions, and their repositioning in the three-dimensional space of the nucleus, are key contributors to the regulation of gene expression.

引用

页码：127 / 133

页数：7

共 83 条

[1] Ordered recruitment of chromatin modifying and general transcription factors to the IFN-β promoter [J].

Agalioti, T ;

Lomvardas, S ;

Parekh, B ;

Yie, JM ;

Maniatis, T ;

Thanos, D .

CELL, 2000, 103 (04) :667-678

[2] Chromosomal Dynamics at the Shh Locus: Limb Bud-Specific Differential Regulation of Competence and Active Transcription [J].

Amano, Takanori ;

Sagai, Tomoko ;

Tanabe, Hideyuki ;

Mizushina, Yoichi ;

Nakazawa, Hiromi ;

Shiroishi, Toshihiko .

DEVELOPMENTAL CELL, 2009, 16 (01) :47-57

[3] Virus infection induces NF-κB-dependent interchromosomal associations mediating monoallelic IFN-β gene expression [J].

Apostolou, Effie ;

Thanos, Dimitris .

CELL, 2008, 134 (01) :85-96

[4]

Bacher CP, 2006, NAT CELL BIOL, V8, P293, DOI 10.1038/ncb1365

[5] Inheritance of Polycomb-dependent chromosomal interactions in Drosophila [J].

Bantignies, F ;

Grimaud, C ;

Lavrov, S ;

Gabut, M ;

Cavalli, G .

GENES & DEVELOPMENT, 2003, 17 (19) :2406-2420

[6] Three-dimensional maps of all chromosomes in human male fibroblast nuclei and prometaphase rosettes [J].

Bolzer, A ;

Kreth, G ;

Solovei, I ;

Koehler, D ;

Saracoglu, K ;

Fauth, C ;

Müller, S ;

Eils, R ;

Cremer, C ;

Speicher, MR ;

Cremer, T .

PLOS BIOLOGY, 2005, 3 (05) :826-842

[7] Intermingling of chromosome territories in interphase suggests role in translocations and transcription-dependent associations [J].

Branco, Miguel R. ;

Pombo, Ana .

PLOS BIOLOGY, 2006, 4 (05) :780-788

[8] Association between active genes occurs at nuclear speckles and is modulated by chromatin environment [J].

Brown, Jill M. ;

Green, Joanne ;

das Neves, Ricardo Pires ;

Wallace, Helen A. C. ;

Smith, Andrew J. H. ;

Hughes, Jim ;

Gray, Nicki ;

Taylor, Steve ;

Wood, William G. ;

Higgs, Douglas R. ;

Iborra, Francisco J. ;

Buckle, Veronica J. .

JOURNAL OF CELL BIOLOGY, 2008, 182 (06) :1083-1097

[9] Coregulated human globin genes are frequently in spatial proximity when active [J].

Brown, JM ;

Leach, J ;

Reittie, JE ;

Atzberger, A ;

Lee-Prudhoe, J ;

Wood, WG ;

Higgs, DR ;

Iborra, FJ ;

Buckle, VJ .

JOURNAL OF CELL BIOLOGY, 2006, 172 (02) :177-187

[10] SATB1 packages densely looped, transcriptionally active chromatin for coordinated expression of cytokine genes [J].

Cai, Shutao ;

Lee, Charles C. ;

Kohwi-Shigematsu, Terumi .

NATURE GENETICS, 2006, 38 (11) :1278-1288

← 1 2 3 4 5 6 7 8 9 →