Animal Models of Temporomandibular Disorder

被引:23
作者
Xiang, Ting [1 ,2 ]
Tao, Zhuo-Ying [3 ]
Liao, Li-Fan [1 ]
Wang, Shuang [2 ]
Cao, Dong-Yuan [1 ]
机构
[1] Xi An Jiao Tong Univ, Coll Stomatol, Res Ctr Stomatol, Key Lab Shaanxi Prov Craniofacial Precis Med Res, Xian 710004, Shaanxi, Peoples R China
[2] Xi An Jiao Tong Univ, Dept Orthodont, Coll Stomatol, Xian 710004, Shaanxi, Peoples R China
[3] Univ Hong Kong, Fac Dent, Discipline Oral & Maxillofacial Surg, Sai Ying Pun, Hong Kong 999077, Peoples R China
来源
JOURNAL OF PAIN RESEARCH | 2021年 / 14卷
基金
中国国家自然科学基金;
关键词
temporomandibular disorder; mechanism; animal model; treatment; ANTIGEN-INDUCED ARTHRITIS; ARTICULAR-CARTILAGE; CONDYLAR CARTILAGE; RABBIT MODEL; JOINT; PAIN; OSTEOARTHRITIS; RATS; DEGENERATION; HYPERALGESIA;
D O I
10.2147/JPR.S303536
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Temporomandibular disorders (TMD) are a group of diseases in the oral and maxillofacial region that can manifest as acute or chronic persistent pain, affecting millions of people worldwide. Although hundreds of studies have explored mechanisms and treatments underlying TMD, multiple pathogenic factors and diverse clinical manifestations make it still poorly managed. Appropriate animal models are helpful to study the pathogenesis of TMD and explore effective treatment measures. At present, due to the high cost of obtaining large animals, rodents and rabbits are often used to prepare TMD animal models. Over the past decade, various animal models have been intensively developed to understand neurobiological and molecular mechanisms of TMD, and seek effective treatments. Although these models cannot carry out all clinical features, they are valuable in revealing the mechanisms of TMD and creating curative access. Currently, there are multitudinous animal models of TMD research. They can be constructed in different means and summarized into four ways according to the various causes and symptoms, including chemical induction (intra-articular injection of ovalbumin, collagenase, formalin, vascular endothelial growth factor, intramuscular injection of complete Freund's adjuvant, etc.), mechanical stress stimulation (passive mouth opening, change of chewing load), surgical operation (partial disc resection, joint disc perforation) and psychological stress induction. Here, we summarize and discuss different approaches of animal models for determining neurophysiological and mechanical mechanisms of TMD and assess their advantages and limitations, respectively.
引用
收藏
页码:1415 / 1430
页数:16
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