Hydrogen Sulfide Improves Vascular Calcification in Rats by Inhibiting Endoplasmic Reticulum Stress

被引：34
|
作者：
Yang, Rui [1 ]
Teng, Xu [1 ,2 ]
Li, Hui [1 ]
Xue, Hong-Mei [1 ]
Guo, Qi [1 ]
Xiao, Lin [1 ]
Wu, Yu-Ming [1 ,3 ,4 ]
机构：
[1] Hebei Med Univ, Inst Basic Med, Dept Physiol, Shijiazhuang 050017, Peoples R China
[2] Hebei Med Univ, Hebei Key Lab Lab Anim Sci, Shijiazhuang 050017, Peoples R China
[3] Hebei Collaborat Innovat Ctr Cardiocerebrovasc Di, Shijiazhuang 050017, Peoples R China
[4] Key Lab Vasc Med Hebei Prov, Shijiazhuang 050017, Peoples R China
来源：
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2016年 / 2016卷
基金：
高等学校博士学科点专项科研基金; 中国国家自然科学基金;
关键词：
CYSTATHIONINE GAMMA-LYASE; TRANSCRIPTION FACTOR 4; SMOOTH-MUSCLE-CELLS; MEDIATED APOPTOSIS; MECHANISMS; PROTECTS; DIFFERENTIATION; REGULATOR; KINASE; INJURY;
D O I：
10.1155/2016/9095242
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
In this study, the vitamin D-3 plus nicotine (VDN) model of rats was used to prove that H2S alleviates vascular calcification (VC) and phenotype transformation of vascular smoothmuscle cells (VSMC). Besides, H2S can also inhibit endoplasmic reticulum stress (ERS) of calcified aortic tissues. The effect of H2S on alleviating VC and phenotype transformation of VSMC can be blocked by TM, while PBA also alleviated VC and phenotype transformation of VSMC that was similar to the effect of H2S. These results suggest that H2S may alleviate rat aorta VC by inhibiting ERS, providing new target and perspective for prevention and treatment of VC.
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页数：9
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