Analysis of Risk Factors of New Fracture of Vertebral Body After Percutaneous Kyphoplasty in Patients with Primary Osteoporotic Fracture of Thoracic and Lumbar Spine

Aim: To investigate the risk factors of vertebral new fractures after percutaneous kyphoplasty (PKP) in patients with primary osteoporotic thoracolumbar fractures. Methods: 182 cases were diagnosed as primary osteoporotic vertebral fractures in our department between November 2012 and October 2014, and 161 cases were followed up. According to whether there were new fractures of the vertebral body after PKP operation, the patients were divided into a group without fractures (n = 148) and a group with new fracture (n = 13). Results: Univariate analysis showed that there were statistically significant differences between the two groups in smoking history, vertebral height recovery rate, bone mineral density and bone cement leakage (P < 0.05). There was no significant difference in age, gender, bone cement infusion, number of fractured vertebrae and seasons of fracture (P > 0.05). Multivariate logistic regression analysis demonstrated that heavy osteoporosis and bone cement leakage were risk factors for vertebral new fracture after PKP operation (P < 0.05). Conclusions: Severe osteoporosis and bone cement leakage are risk factors of vertebral new fractures after PKP in patients with primary osteoporotic thoracolumbar fractures. Our findings suggest a requirement for anti-osteoporosis treatment after PKP operation for patients with primary osteoporotic thoracolumbar fractures.