Lipid droplet growth by fusion: insights from freeze-fracture imaging

被引：5

作者：

Robenek, Horst ^{[1
]}

Severs, Nicholas J. ^{[2
]}

机构：

[1] Univ Munster, Leibniz Inst Arteriosclerosis Res, Dept Cell Biol & Ultrastruct Res, D-48149 Munster, Germany

[2] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Div, London, England

来源：

JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2009年 / 13卷 / 11-12期

关键词：

lipid droplet fusion freeze-fracture electron microscopy immunogold cytochemistry; PROTEIN;

D O I：

10.1111/j.1582-4934.2009.00950.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

An understanding of how lipid droplets grow in the cell is important to current human health issues. Homotypic fusion of small lipid droplets to create larger ones is one proposed mechanism though the evidence for this process continues to be debated. By applying the technique of freeze-fracture electron microscopy to cells that have been stimulated to accumulate lipid droplets, we here present images which suggest that at least some large lipid droplets may indeed result from amalgamation of multiple smaller ones. These visual data add significantly to the notion that fusion contributes to lipid droplet growth.

引用

页码：4657 / 4661

页数：5