Complete protection against lethal challenge of novel H7N9 virus with heterologous inactivated H7 vaccine in mice

被引：8
作者：
Tang, Lay Hoon [1 ]
Lim, Jie Hui [1 ]
Kuah, Li Fang [1 ]
Lau, Yuk Fai [1 ,2 ]
机构：
[1] DSO Natl Labs, Host Pathogen Interact Lab, DMERI, Singapore 117510, Singapore
[2] Duke NUS Grad Med Sch, Program Emerging Infect Dis, Singapore 169857, Singapore
来源：
VACCINE | 2014年 / 32卷 / 42期
关键词：
Influenza; H7N9; Vaccine; INFLUENZA-A VIRUS; CONVALESCENT PLASMA; PATHOGENICITY; INFECTION;
D O I：
10.1016/j.vaccine.2014.07.087
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A prototype H7 influenza vaccine constructed based on the H7N7 outbreak in 2003 was tested for the protective efficacy against the novel H7N9 virus in a lethal murine challenge model. Serum samples from vaccinated mice showed significant neutralizing activity against the H7N9 virus and the mice were completely protected with no significant weight loss. The results have direct implications on how to overcome potential vaccine shortage and identify donors for immune sera for passive immunization. (C) 2014 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5375 / 5378
页数：4
相关论文
共 16 条
[1]   Past, Present, and Possible Future Human Infection with Influenza Virus A Subtype H7 [J].
Belser, Jessica A. ;
Bridges, Carolyn B. ;
Katz, Jacqueline M. ;
Tumpey, Terrence M. .
EMERGING INFECTIOUS DISEASES, 2009, 15 (06) :859-865
[2]   A Randomized Clinical Trial of an Inactivated Avian Influenza A (H7N7) Vaccine [J].
Couch, Robert B. ;
Patel, Shital M. ;
Wade-Bowers, Chianti L. ;
Nino, Diane .
PLOS ONE, 2012, 7 (12)
[3]   Protection of mice against lethal infection with highly pathogenic H7N7 influenza A virus by using a recombinant low-pathogenicity vaccine strain [J].
de Wit, E ;
Munster, VJ ;
Spronken, MIJ ;
Bestebroer, TM ;
Baas, C ;
Beyer, WEP ;
Rimmelzwaan, GF ;
Osterhaus, ADME ;
Fouchier, RAM .
JOURNAL OF VIROLOGY, 2005, 79 (19) :12401-12407
[4]   Avian influenza A virus (H7N7) associated with human conjunctivitis and a fatal case of acute respiratory distress syndrome. [J].
Fouchier, RAM ;
Schneeberger, PM ;
Rozendaal, FW ;
Broekman, JM ;
Kemink, SAG ;
Munstert, V ;
Kuiken, T ;
Rimmelzwaan, GF ;
Schutten, M ;
van Doornum, GJJ ;
Koch, G ;
Bosman, A ;
Koopmans, M ;
Osterhaus, ADME .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (05) :1356-1361
[5]   A Recombinant Viruslike Particle Influenza A (H7N9) Vaccine [J].
Fries, Louis F. ;
Smith, Gale E. ;
Glenn, Gregory M. .
NEW ENGLAND JOURNAL OF MEDICINE, 2013, 369 (26) :2564-2566
[6]   A DNA transfection system for generation of influenza A virus from eight plasmids [J].
Hoffmann, E ;
Neumann, G ;
Kawaoka, Y ;
Hobom, G ;
Webster, RG .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (11) :6108-6113
[7]   Convalescent Plasma Treatment Reduced Mortality in Patients With Severe Pandemic Influenza A (H1N1) 2009 Virus Infection [J].
Hung, Ivan F. N. ;
To, Kelvin K. W. ;
Lee, Cheuk-Kwong ;
Lee, Kar-Lung ;
Chan, Kenny ;
Yan, Wing-Wah ;
Liu, Raymond ;
Watt, Chi-Leung ;
Chan, Wai-Ming ;
Lai, Kang-Yiu ;
Koo, Chi-Kwan ;
Buckley, Tom ;
Chow, Fu-Loi ;
Wong, Kwan-Keung ;
Chan, Hok-Sum ;
Ching, Chi-Keung ;
Tang, Bone S. F. ;
Lau, Candy C. Y. ;
Li, Iris W. S. ;
Liu, Shao-Haei ;
Chan, Kwok-Hung ;
Lin, Che-Kit ;
Yuen, Kwok-Yung .
CLINICAL INFECTIOUS DISEASES, 2011, 52 (04) :447-456
[8]   A live attenuated cold-adapted influenza A H7N3 virus vaccine provides protection against homologous and heterologous H7 viruses in mice and ferrets [J].
Joseph, Tomy ;
McAuliffe, Josephine ;
Lu, Bin ;
Vogel, Leatrice ;
Swayne, David ;
Jin, Hong ;
Kemble, George ;
Subbarao, Kanta .
VIROLOGY, 2008, 378 (01) :123-132
[9]   Evaluation of replication and pathogenicity of avian influenza a h7 subtype viruses in a mouse model [J].
Joseph, Tomy ;
McAuliffe, Josephine ;
Lu, Bin ;
Jin, Hong ;
Kemble, George ;
Subbarao, Kanta .
JOURNAL OF VIROLOGY, 2007, 81 (19) :10558-10566
[10]   MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines [J].
Khurana, Surender ;
Verma, Nitin ;
Yewdell, Jonathan W. ;
Hilbert, Anne Katrin ;
Castellino, Flora ;
Lattanzi, Maria ;
Del Giudice, Giuseppe ;
Rappuoli, Rino ;
Golding, Hana .
SCIENCE TRANSLATIONAL MEDICINE, 2011, 3 (85)
12