Iron-Catalyzed Selective N-Methylation and N-Formylation of Amines with CO2

被引：59
|
作者：
Li, Wen-Duo [1 ,2 ]
Zhu, Dao-Yong [1 ]
Li, Gang [1 ]
Chen, Jie [1 ]
Xia, Ji-Bao [1 ]
机构：
[1] Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Suzhou Res Inst LICP, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 22期
关键词：
Iron; Mono-phosphine; Carbon dioxide; N-methylation; N-formylation; CARBON-DIOXIDE; HETEROCYCLIC CARBENE; REDUCTIVE FUNCTIONALIZATION; COMPUTATIONAL DESIGN; IONIC LIQUIDS; BASE-METAL; C-O; HYDROGENATION; TRANSFORMATION; HYDROSILANE;
D O I：
10.1002/adsc.201900906
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
We herein describe an efficient iron-catalyzed selective N-methylation and N-formylation of amines with CO2 and silane using mono-phosphine as ligand. With commercially available [CpFe(CO)(2)](2) as catalyst, Fe-catalyzed methylation of amines was achieved with triphenylphosphine as a ligand. Using tributylphosphine as a ligand, Fe-catalyzed formylation of amines was realized at a lower temperature. The method was successfully applied in the late-stage methylation and formylation of drug molecules containing amine moiety.
引用
收藏
页码：5098 / 5104
页数：7
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