Iron-Catalyzed Selective N-Methylation and N-Formylation of Amines with CO2

被引：59

作者：

Li, Wen-Duo ^{[1
,2
]}

Zhu, Dao-Yong ^{[1
]}

Li, Gang ^{[1
]}

Chen, Jie ^{[1
]}

Xia, Ji-Bao ^{[1
]}

机构：

[1] Chinese Acad Sci, State Key Lab Oxo Synth & Select Oxidat, Suzhou Res Inst LICP, Lanzhou Inst Chem Phys, Lanzhou 730000, Gansu, Peoples R China

[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2019年 / 361卷 / 22期

关键词：

Iron; Mono-phosphine; Carbon dioxide; N-methylation; N-formylation; CARBON-DIOXIDE; HETEROCYCLIC CARBENE; REDUCTIVE FUNCTIONALIZATION; COMPUTATIONAL DESIGN; IONIC LIQUIDS; BASE-METAL; C-O; HYDROGENATION; TRANSFORMATION; HYDROSILANE;

D O I：

10.1002/adsc.201900906

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We herein describe an efficient iron-catalyzed selective N-methylation and N-formylation of amines with CO2 and silane using mono-phosphine as ligand. With commercially available [CpFe(CO)(2)](2) as catalyst, Fe-catalyzed methylation of amines was achieved with triphenylphosphine as a ligand. Using tributylphosphine as a ligand, Fe-catalyzed formylation of amines was realized at a lower temperature. The method was successfully applied in the late-stage methylation and formylation of drug molecules containing amine moiety.

引用

页码：5098 / 5104

页数：7

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