Transcriptional impairment of β-catenin/E-cadherin complexis not associated with β-catenin mutations in colorectal carcinomas

被引：8

作者：

Garinis, GA

Spanakis, NE

Menounos, OG

Manolis, EN

Peros, G

机构：

[1] Nursing Mil Acad, Res Lab, Athens, Greece

[2] Nikaia Hosp, Dept Surg, Athens, Greece

[3] Univ Athens, Sch Nursing, Dept Anat & Histol, Athens, Greece

来源：

BRITISH JOURNAL OF CANCER | 2003年 / 88卷 / 02期

关键词：

colorectal; beta-catenin; mRNA; mutations;

D O I：

10.1038/sj.bjc.6600706

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

We report the absence of beta-catenin mutations in 63 sporadic colorectal carcinomas (SCRCs) with demonstrated decreased beta-catenin and E-cadherin mRNA expression and E-cadherin protein expression in a subset of carcinomas examined, suggesting that beta-catenin mutations are an extremely rare phenomenon in SCRCs and are not responsible for the transcriptional impairment of the beta-catenin/E-cadherin adhesion complex observed in these tumours. (C) 2003 Cancer Research UK.

引用

页码：206 / 209

页数：4

共 13 条

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ALEXANDER N, 2002, AM J PATHOL, V160, P389

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