共 19 条
Human mast cells express androgen receptors but treatment with testosterone exerts no influence on IgE-independent mast cell degranulation elicited by neuromuscular blocking agents
被引:67
作者:
Chen, WenChieh
[1
,2
]
Beck, Isabelle
[2
]
Schober, Wolfgang
[2
]
Brockow, Knut
[1
]
Effner, Renate
[2
]
Buters, Jeroen T. M.
[2
]
Behrendt, Heidrun
[2
]
Ring, Johannes
[1
]
机构:
[1] Tech Univ Munich, Dept Dermatol & Allergy, D-80802 Munich, Germany
[2] Tech Univ Munich, Ctr Allergy & Environm, Helmholtz Zentrum Munchen TUM, Div Environm Dermatol & Allergy,ZAUM, D-80802 Munich, Germany
关键词:
androgen receptor;
mast cell;
neuromuscular blocking agent;
oestrogen receptor;
testosterone;
MUSCLE-RELAXANTS;
SEX-HORMONES;
ANESTHESIA;
ANAPHYLAXIS;
ACTIVATION;
PATIENT;
RISK;
LINE;
D O I:
10.1111/j.1600-0625.2009.00969.x
中图分类号:
R75 [皮肤病学与性病学];
学科分类号:
100206 ;
摘要:
Women predominate in the anaphylactic reactions to neuromuscular blocking agents (NMBA). The expression of oestrogen receptors has been demonstrated in mast cells and oestrogen treatment can enhance mast cell degranulation, but the influence of androgens remains largely unclear. Our immunocytochemical study showed the expression of androgen receptor (AR) in mast cells isolated from human foreskin as well as in two human mast cell lines, HMC-1 and LAD2. The amount of AR was most abundant in human skin mast cells as determined by real-time polymerase chain reaction analysis. Treatment of the HMC-1 mast cells with testosterone or 17 beta-oestradiol, alone or in combination with different NMBA, did not affect mast cell degranulation as measured by the release of beta-hexosaminidase. Our study shows for the first time the expression of AR in human skin mast cells. Further studies using primary human mast cell cultures are needed to understand whether and how sex hormones can influence mast cell activation.
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页码:302 / 304
页数:3
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