Facile construction of targeted pH-responsive DNA-conjugated gold nanoparticles for synergistic photothermal-chemotherapy

被引：36
作者：
Chen, Bo [1 ,2 ,3 ]
Mei, Lan [1 ,2 ,3 ]
Fan, Rangrang [1 ,2 ,3 ]
Wang, Yuelong [1 ,2 ,3 ]
Nie, Chunlai [1 ,2 ,3 ]
Tong, Aiping [1 ,2 ,3 ]
Guo, Gang [1 ,2 ,3 ]
机构：
[1] Sichuan Univ, West China Hosp, State Key Lab Biotherapy, Chengdu 610041, Peoples R China
[2] Sichuan Univ, West China Hosp, Canc Ctr, Chengdu 610041, Peoples R China
[3] Collaborat Innovat Ctr Biotherapy, Chengdu 610041, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2021年 / 32卷 / 05期
关键词：
Gold nanoparticles; i-Motif; Freeze-thaw; MUC1; aptamer; Photothermal-chemotherapy; CANCER; OLIGONUCLEOTIDES; DOXORUBICIN; THERAPY; ORIGAMI; SURFACE;
D O I：
10.1016/j.cclet.2020.12.058
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Recently, stimuli-responsive DNA nanostructure-based nanodevices have been applied for cancer therapy. In this study, pH-responsive i-motif DNA was modified on gold nanoparticles (AuNPs) via a facile, time-saving freeze-thaw method and utilized to construct stimuli-responsive drug nanocarriers. When the environment pH changes from 7.4 to 5.0, the i-motif DNA would be folded into four-stranded (C-quadruplex) that could be characterized by circular dichroism, and the characteristic of acid stimulate was verified by fluorescence resonance energy transfer (FRET). To enhance specifical cellular uptake, MUC1 aptamer was employed as the targeting moiety. Doxorubicin (Dox) is an anticancer drug that can be efficiently intercalated into GC base pairs of DNA nanostructure to form drug-loaded nanovehicles (Dox@AuNP-MUC1). Additionally, owing to the excellent photothermal conversion efficiency of AuNPs, the synergistic effect between chemotherapy and PTT can be readily achieved by 808 nm near-infrared (NIR) irradiation, which exhibits specifically and efficiently anticancer efficiency. Hence, this multifunctional drug carrier shows the potential for synergistic photothermal-chemotherapy. (c) 2021 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.
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收藏
页码：1775 / 1779
页数：5
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