Toward therapeutic electrophysiology: beta-band suppression as a biomarker in chronic local field potential recordings

被引：72

作者：

Feldmann, Lucia K. ^{[1
,2
,3
,4
]}

Lofredi, Roxanne ^{[1
,2
,3
]}

Neumann, Wolf-Julian ^{[1
,2
,3
]}

Al-Fatly, Bassam ^{[1
,2
,3
]}

Roediger, Jan ^{[1
,2
,3
,5
]}

Bahners, Bahne H. ^{[6
,7
]}

Nikolov, Petyo ^{[6
,7
]}

Denison, Timothy ^{[8
]}

Saryyeva, Assel ^{[9
]}

Krauss, Joachim K. ^{[9
]}

Faust, Katharina ^{[2
,3
,10
]}

Florin, Esther ^{[6
]}

Schnitzler, Alfons ^{[7
]}

Schneider, Gerd-Helge ^{[2
,3
,10
]}

Kuehn, Andrea A. ^{[1
,2
,3
,11
,12
,13
]}

机构：

[1] Charite Univ Med Berlin, Dept Neurol, Berlin, Germany

[2] Free Univ Berlin, Berlin, Germany

[3] Humboldt Univ, Berlin, Germany

[4] Charite Univ Med Berlin, Berlin Inst Hlth, Berlin, Germany

[5] Charite Univ Med Berlin, Einstein Ctr Neurosci Berlin, D-10117 Berlin, Germany

[6] Heinrich Heine Univ Dusseldorf, Med Fac, Inst Clin Neurosci & Med Psychol, Dusseldorf, Germany

[7] Movement Disorder & Neuromodulat Ctr, Med Fac, Dept Neurol, Dusseldorf, Germany

[8] Univ Oxford, Nuffield Dept Clin Neurosci, Brain Network Dynam Unit, MRC, Oxford, England

[9] Med Sch Hannover, Dept Neurosurg, Hannover, Germany

[10] Charite Univ Med Berlin, Dept Neurosurg, Berlin, Germany

[11] Charite Univ Med Berlin, Berlin Sch Mind & Brain, Berlin, Germany

[12] Charite Univ Med Berlin, NeuroCure Clin Res Ctr, Berlin, Germany

[13] German Ctr Degenerat Dis, DZNE, Berlin, Germany

来源：

NPJ PARKINSONS DISEASE | 2022年 / 8卷 / 01期

关键词：

DEEP BRAIN-STIMULATION; PARKINSONS-DISEASE; SUBTHALAMIC NUCLEUS; PATHOLOGICAL SYNCHRONIZATION; OSCILLATORY ACTIVITY; BRADYKINESIA; IMPROVEMENT; MODULATION; REDUCTION; DYNAMICS;

D O I：

10.1038/s41531-022-00301-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Adaptive deep brain stimulation (aDBS) is a promising concept for feedback-based neurostimulation, with the potential of clinical implementation with the sensing-enabled Percept neurostimulator. We aim to characterize chronic electrophysiological activity during stimulation and to validate beta-band activity as a biomarker for bradykinesia. Subthalamic activity was recorded during stepwise stimulation amplitude increase OFF medication in 10 Parkinson's patients during rest and finger tapping. Offline analysis of wavelet-transformed beta-band activity and assessment of inter-variable relationships in linear mixed effects models were implemented. There was a stepwise suppression of low-beta activity with increasing stimulation intensity (p = 0.002). Low-beta power was negatively correlated with movement speed and predictive for velocity improvements (p < 0.001), stimulation amplitude for beta suppression (p < 0.001). Here, we characterize beta-band modulation as a chronic biomarker for motor performance. Our investigations support the use of electrophysiology in therapy optimization, providing evidence for the use of biomarker analysis for clinical aDBS.

引用

页数：9

共 56 条

[1] Long-term Recordings of Local Field Potentials From Implanted Deep Brain Stimulation Electrodes [J].

Abosch, Aviva ;

Lanctin, David ;

Onaran, Ibrahim ;

Eberly, Lynn ;

Spaniol, Maggie ;

Ince, Nuri Firat .

NEUROSURGERY, 2012, 71 (04) :804-814

[2] Lack of progression of beta dynamics after long-term subthalamic neurostimulation [J].

Anderson, Ross W. ;

Wilkins, Kevin B. ;

Parker, Jordan E. ;

Petrucci, Matthew N. ;

Kehnemouyi, Yasmine ;

Neuville, Raumin S. ;

Cassini, Declan ;

Trager, Megan H. ;

Koop, Mandy M. ;

Velisar, Anca ;

Blumenfeld, Zack ;

Quinn, Emma J. ;

Henderson, Jaimie ;

Bronte-Stewart, Helen M. .

ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY, 2021, 8 (11) :2110-2120

[3] Neuromodulation targets pathological not physiological beta bursts during gait in Parkinson's disease [J].

Anidi, Chioma ;

O'Day, Johanna J. ;

Anderson, Ross W. ;

Afzal, Muhammad Furcian ;

Syrkin-Nikolau, Judy ;

Velisar, Anca ;

Bronte-Stewart, Helen M. .

NEUROBIOLOGY OF DISEASE, 2018, 120 :107-117

[4] Monitoring Subthalamic Oscillations for 24 Hours in a Freely Moving Parkinson's Disease Patient [J].

Arlotti, Mattia ;

Palmisano, Chiara ;

Minafra, Brigida ;

Todisco, Massimiliano ;

Pacchetti, Claudio ;

Canessa, Andrea ;

Pozzi, Nicolo G. ;

Cilia, Roberto ;

Prenassi, Marco ;

Marceglia, Sara ;

Priori, Alberto ;

Rampini, Paolo ;

Barbieri, Sergio ;

Servello, Domenico ;

Volkmann, Jens ;

Pezzoli, Gianni ;

Isaias, Ioannis U. .

MOVEMENT DISORDERS, 2019, 34 (05) :757-759

[5] Eight-hours adaptive deep brain stimulation in patients with Parkinson disease [J].

Arlotti, Mattia ;

Marceglia, Sara ;

Foffani, Guglielmo ;

Volkmann, Jens ;

Lozano, Andres M. ;

Moro, Elena ;

Cogiamanian, Filippo ;

Prenassi, Marco ;

Bocci, Tommaso ;

Cortese, Francesca ;

Rampini, Paolo ;

Barbieri, Sergio ;

Priori, Alberto .

NEUROLOGY, 2018, 90 (11) :E971-506

[6] Independently together: subthalamic theta and beta opposite roles in predicting Parkinson's tremor [J].

Asch, Nir ;

Herschman, Yehuda ;

Maoz, Rotem ;

Auerbach-Asch, Carmel R. ;

Valsky, Dan ;

Abu-Snineh, Muneer ;

Arkadir, David ;

Linetsky, Eduard ;

Eitan, Renana ;

Marmor, Odeya ;

Bergman, Hagai ;

Israel, Zvi .

BRAIN COMMUNICATIONS, 2020, 2 (02)

[7] Symmetric diffeomorphic image registration with cross-correlation: Evaluating automated labeling of elderly and neurodegenerative brain [J].

Avants, B. B. ;

Epstein, C. L. ;

Grossman, M. ;

Gee, J. C. .

MEDICAL IMAGE ANALYSIS, 2008, 12 (01) :26-41

[8] Tremor Reduction by Deep Brain Stimulation Is Associated With Gamma Power Suppression in Parkinson's Disease [J].

Beudel, Martijn ;

Little, Simon ;

Pogosyan, Alek ;

Ashkan, Keyoumars ;

Foltynie, Thomas ;

Limousin, Patricia ;

Zrinzo, Ludvic ;

Hariz, Marwan ;

Bogdanovic, Marko ;

Cheeran, Binith ;

Green, Alexander L. ;

Aziz, Tipu ;

Thevathasan, Wesley ;

Brown, Peter .

NEUROMODULATION, 2015, 18 (05) :349-354

[9] Eight-hours conventional versus adaptive deep brain stimulation of the subthalamic nucleus in Parkinson's disease [J].

Bocci, Tommaso ;

Prenassi, Marco ;

Arlotti, Mattia ;

Cogiamanian, Filippo Maria ;

Borrellini, Linda ;

Moro, Elena ;

Lozano, Andres M. ;

Volkmann, Jens ;

Barbieri, Sergio ;

Priori, Alberto ;

Marceglia, Sara .

NPJ PARKINSONS DISEASE, 2021, 7 (01)

[10] The STN beta-band profile in Parkinson's disease is stationary and shows prolonged attenuation after deep brain stimulation [J].

Bronte-Stewart, Helen ;

Barberini, Crista ;

Koop, Mandy Miller ;

Hill, Bruce C. ;

Henderson, Jairnie M. ;

Wingeier, Brett .

EXPERIMENTAL NEUROLOGY, 2009, 215 (01) :20-28

← 1 2 3 4 5 6 →